My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Smurf1-IN-A01
    Smurf1-IN-A01

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V4432
    CAS #: 1007647-73-5Purity ≥98%

    Description: Smurf1-IN-A01 is a novel, potent, high affinity and selective inhibitor of E3 ubiquitin-protein ligase Smurf1 (Smad ubiquitination regulatory factor-1) with Kd value of 3.7 nM. It disturbs Smurf1-Smad1/5 interaction and blocks Smurf1 mediated Smad1/5 ubiquitination. Smurf1-IN-A01 increases responsiveness to BMP-2 in myoblasts and osteoblasts. The ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) negatively regulates bone morphogenetic protein (BMP) pathway by ubiquitinating certain signal components for degradation. Thus, it can be an eligible pharmacological target for increasing BMP signal responsiveness. 

    References:  2014 May 14;4:4965. 


    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
     

    Smurf1-IN-A01

    Name: Smurf1-IN-A01
    CAS#: 1007647-73-5
    Chemical Formula: C22H20ClF3N4O3S
    Exact Mass: 512.0897
    Molecular Weight: 512.93
    Elemental Analysis: C, 51.52; H, 3.93; Cl, 6.91; F, 11.11; N, 10.92; O, 9.36; S, 6.25
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: Smurf1-IN-A01; Smurf1INA01; Smurf1 IN A01; Smurf1 inhibitor A01; Smurf1-inhibitor-A01;
    IUPAC/Chemical Name: [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]-methanone
    InChi Key: QFYLTUDRXBNZFQ-UHFFFAOYSA-N
    InChi Code: InChI=1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3
    SMILES Code: O=C(N1CCN(S(=O)(C2=CC=C(Cl)C(C(F)(F)F)=C2)=O)CC1)C3=CC=C(N4N=CC=C4C)C=C3


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2

    These protocols are for reference only. InvivoChem does not independently validate these methods.

     Smurf1-IN-A01


    Primary selection of potential bio-active compounds. (a) Determination of the efficacy of various selected compounds of enhancing BMP induced ALP activity. (b) Chemical structures of A01 and A17.   2014 May 14;4:4965.

     Smurf1-IN-A01


    Selective compounds stabilize Smad1/5 protein level.  2014 May 14;4:4965.

     Smurf1-IN-A01


    Selective compounds impair Smurf1-mediated Smad1/5 degradation.  2014 May 14;4:4965.

     Smurf1-IN-A01


    Selective compounds enhance BMP-2 signaling responsiveness.

    Smurf1-IN-A01

    Predicted binding modes of selective compounds to the defined pocket.  2014 May 14;4:4965.

     Smurf1-IN-A01


    Selective compounds potentiate BMP-2 induced osteoblastic activity.  2014 May 14;4:4965.

     Smurf1-IN-A01


    Binding pocket definition and in silico screening. a) Refined structure of the Smurf1 WW1 domain bound to the diphosphorylated (pS210/pS214) region of the Smad1 linker. (b) Refined structure of the Smurf1 WW1 domain bound to the monophosphorylated (pS214) region of the Smad1 linker. (c) Receptor model of the Smurf1 WW1 domain (multiple colored) and diphosphorylated (pS210/pS214) region of the Smad1 linker (yellow). (d) Workflow of in silicoscreening.


    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?