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    8-Bromo-cAMP
    8-Bromo-cAMP

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1847
    CAS #: 76939-46-3Purity ≥98%

    Description:  8-Bromo-cAMP is a potent and cell permeable cyclic AMP (cAMP) analog and a PKA activator. 8-Bromo-cAMP increased the cellular content of mRNA encoding the hCG a- and β-subunits and prevented the increase in fibronectin mRNA. This is determined by blot hybridization analysis using specific cDNA probes. 8-Bromo-cAMP also induced phosphorylation of Erk1,2 in AML193 cells. 8-Bromo-cAMP is an agent in AML193 cells and activates Erk1,2 , this condition happens does not accompanied by the involvement of Shc phosphorylation.

    ReferencesStem Cell Rev. 2011 Jun;7(2):331-41; Am J Physiol Lung Cell Mol Physiol. 2014 Oct 15;307(8):L643-51. 

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    Molecular Weight (MW)430.08 
    FormulaC10H10BrN5NaO6P 
    CAS No.76939-46-3 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 80 mg/mL (186.01 mM)
    Water: < 1 mg/mL
    Ethanol: 35 mg/mL (81.38 mM)
    Other info

    Chemical Name: sodium (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide

    InChi Key: DMRMZQATXPQOTP-GWTDSMLYSA-M

    InChi Code: InChI=1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1

    SMILES Code: O[[email protected]]1[[email protected]@H](O[[email protected]]2[[email protected]]1OP(OC2)([O-])=O)N3C(Br)=NC4=C3N=CN=C4N.[Na+]

    Synonyms

    8 Br cAMP Na; 8BrcAMP sodium; 8-Br-cAMP Na


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    In Vitro

    In vitro activity: 8-Bromo-cAMP improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. In bronchial epithelial cells, 8-Bromo-cAMP decreases HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE; ADAM-17) activity and subsequent TNF-α release.


    Cell Assay: 8-Bromo-cAMP increased the cellular content of mRNA encoding the hCG a- and β-subunits and prevented the increase in fibronectin mRNA. This is determined by blot hybridization analysis using specific cDNA probes. 8-Bromo-cAMP also induced phosphorylation of Erk1,2 in AML193 cells. 8-Bromo-cAMP is an agent in AML193 cells and activates Erk1,2 , this condition happens does not accompanied by the involvement of Shc phosphorylation. 

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    References

    Stem Cell Rev. 2011 Jun;7(2):331-41; Am J Physiol Lung Cell Mol Physiol. 2014 Oct 15;307(8):L643-51.  


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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