Potassium Channel

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Potassium Channel

Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.

Potassium Channel related products

Cat No.	Product Name	CAS No.	Product Description
V4002	ML365	947914-18-3	ML365 is a potent, novel and selective small molecule inhibitor of the TASK1(KCNK3, a two-pore domain potassium channel).
V4016	ML402	298684-44-3	ML402 (ML-402) is a potent and selective activator of TREK-1/-2and an agonist for OPRM1-OPRD1 (OPRM1: opioid receptor mu 1; OPRD1: delta opioid receptor) heterdimerization.
V73592	ML67-33	1443290-89-8	ML67-33 is a selective activator of temperature- and mechanically-sensitive K2P channels.
V91075	Nalanthalide	145603-76-5	Nalanthalide is a voltage-gated potassium channel (Potassium Channel) Kv1.3 blocker (IC50=3.9 µM) and potential immunosuppressant.
V89791	Nav1.8-IN-7	2761181-58-0	Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor.
V94637	Nerispirdine	119229-65-1	Nerispirdine is an ion channel inhibitor with IC50 values of 3.6, 3.7 and 11.9 μM for K(v)1.1, K(v)1.2 and voltage-dependent Na(+) channels, respectively.
V73620	Nicorandil-d4 (Nicorandil d4)	1132681-23-2	Nicorandil-d4 is the deuterium labelled form of Nicorandil.
V73657	Noxiustoxin	85205-49-8	Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius that blocks voltage-dependent potassium channels (Kv1.3, IC50=360 nM) and calcium-activated potassium channels.
V85801	NPBA	524033-40-7
V11738	NS-11021	956014-19-0	NS-11021 is a novel, potent and selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1).
V2831	NS-1643	448895-37-2	NS1643 is a novel and potent human ether-a-go-go related gene (hERG) KV11 channel activator with EC50 of 10.5 μM.
V21754	NS-5806	426834-69-7	NS-5806 (NS5806) is a novel and potent potassium currentKV4.3 channel activator whichincreases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM.
V2809	NS1619	153587-01-0	NS-1619 is a selective activator of the large conductance Ca2+-activated K+-channel (BKCa, KCa1.1).
V73591	NS19504	327062-46-4	NS19504 is a Ca2+-activated K+ channel (BK channel) activator (EC50=11.0 µM) that has a relaxing effect on spontaneous phasic contractions of bladder smooth muscle.
V26675	NS309	18711-16-5	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels).
V26676	NS3623	343630-41-1	NS3623 (NS-3623) is a novel and potent (hERG) and KV4.3 channel activator withantiarrhythmic effects.
V2816	NS6180	353262-04-1	NS6180 is a novel potent and selective KCa3.1 channel inhibitor with IC50 of 9 nM.
V73654	OSK-1	183815-75-0	OSK-1 is an effective Kv channel blocker, with IC50s of 0.6 nM, 5.4 nM and 0.014 nM for Kv1.1, Kv1.2 and Kv1.3 respectively.
V70540	Oxybutynin-d11 chloride (oxybutynin d11 (chloride))	1185151-95-4	Oxybutynin-d11 (chloride) is the deuterated form of Oxybutynin chloride.
V73630	P-CAB agent 2	1978371-23-1	P-CAB agent 2 is a potent and orally bioactive potassium-competitive acid blocker and gastric acid secretion inhibitor.