Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V79246 | Azimilide-d8 dihydrochloride (NE-10064-dd8 (dihydrochloride)) | Azimilide-d8 (di-HCl) is the deuterated form of Azimilide di-HCl. | |
|
V92123 | BA6b9 | 609335-29-7 | BA6b9 is an allosteric inhibitor of SK4 channels that targets the CaM-PIP2 binding domain. |
|
V1933 | BAPTA-AM | 126150-97-8 | BAPTA-AM is a selective, membrane-permeable andintracellularcalcium chelator. |
|
V89157 | Barium chloride dihydrate, 99.5% | 10326-27-9 | Barium chloride dihydrate, 99.5% (Dichlorobarium dihydrate, 99.5%) is a potassium channel blocker. |
|
V73648 | BDS-I | 207621-38-3 | BDS-I, also known as blood-lowering substances, is a marine toxin found in the sulcata anemone flower. |
|
V73604 | BeKm-1 | 524962-01-4 | BeKm-1 is a HERG (human ethera-go-go-related gene) blocking compound. |
|
V78365 | BeKm-1 TFA | BeKm-1 TFA is a potent and specific KV11.1 (hERG) channel blocker. | |
|
V98110 | Besipirdine hydrochloride | 130953-69-4 | Besipiridine (hydrochloride) is a potassium channel blocker with cholinergic and adrenergic activities. |
|
V99967 | Bimokalner | 2243284-19-5 | Bimokalner (Bimokalnerum) is a voltage-gated potassium channel (Kv7.4) agonist. |
|
V130365 | BKCa activator-1 | BKCa activator-1 is an orally effective calcium-activated potassium channel BKCa activator with an EC50 value of 2.82 μM. | |
|
V92122 | BML264 | 99196-74-4 | BML264 ((E)-N-(p-amylcinnamoyl) anthranilic acid) is a TREK-1 agonist. |
|
V78491 | BmP02 | BmP02 is a selective Kv1.3 channel blocker and selective Kv4.2 modulator extracted from the venom of the Chinese scorpion (Buthus martensi Karsch). | |
|
V3481 | BMS-191095 | 166095-21-2 | BMS-191095 is a novel and potent activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. |
|
V103289 | BMS-191095 hydrochloride | 166095-95-0 | BMS-191095 hydrochloride is a mitochondrial KATP channel opener that can protect the myocardium without causing vasodilation or affecting electrophysiology. It exerts a cardioprotective effect by prolonging the myocardial contraction time during ischemia, improving contractile function after reperfusion, and reducing the release of lactate dehydrogenase (LDH). |
|
V87217 | BMS-986308 | 2254333-97-4 | BMS-986308 is a selective and orally active renal extramedullary potassium (ROMK) channel inhibitor. |
|
V115106 | BRL-32872 | 113241-47-7 | BRL-32872 is a potent human ether-a-go-go-related gene (hERG) potassium channel blocker (IC50 value of 241 nM in isolated cardiomyocytes; 19.8 nM in HEK293 cells). |
|
V114890 | BTS-67582 | 161748-40-9 | BTS-67582 is an orally effective non-sulfonylurea insulin secretagogue and potassium channel blocker. |
|
V114677 | C3001a | 2415154-29-7 | C3001a is a selective TREK-1 and TREK-2 channel activator with EC50 values of 12.81 μM and 11.31 μM, respectively. |
|
V116168 | CAT335 | 3032789-44-6 | CAT335 is a TREK activator. |
|
V111018 | Cavutilide hydrochloride | 1276021-10-3 | Carvedilide hydrochloride (nifedilide) is a class III antiarrhythmic drug that inhibits hERG potassium channels. |
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