Seven cation permeable ligand-gated ion channels (LGICs) known as P2X receptors (P2X1R-P2X7R) are a family of LGICs that open in response to the extracellular ligand adenosine 5′-triphosphate (ATP) binding. P2X receptors are widely expressed in the nervous, immune, cardiovascular, skeletal, gastrointestinal, respiratory, and endocrine systems and have a high permeability to Ca2+, Na+, and K+.
P2X receptors are extensively expressed in both excitatory and non-excitatory cells, including neuron, glia, platelet, epithelia, and macrophages. They play a key role in a number of critical physiological and pathological processes, such as synaptic transmission, pain perception, inflammation, cardiovascular regulation, immune modulation, and tumorigenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73558 | α,β-Methylene-ATP trisodium | 1343364-54-4 | α,β-Methylene-ATP trisodium is a phosphonate analog of ATP and a ligand for P2X3 and P2X7 receptors. |
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