Seven cation permeable ligand-gated ion channels (LGICs) known as P2X receptors (P2X1R-P2X7R) are a family of LGICs that open in response to the extracellular ligand adenosine 5′-triphosphate (ATP) binding. P2X receptors are widely expressed in the nervous, immune, cardiovascular, skeletal, gastrointestinal, respiratory, and endocrine systems and have a high permeability to Ca2+, Na+, and K+.
P2X receptors are extensively expressed in both excitatory and non-excitatory cells, including neuron, glia, platelet, epithelia, and macrophages. They play a key role in a number of critical physiological and pathological processes, such as synaptic transmission, pain perception, inflammation, cardiovascular regulation, immune modulation, and tumorigenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73570 | MRS4719 | 2840581-32-8 | MRS4719 is a potent P2X4 receptor antagonist (inhibitor) with IC50 of 0.503 μM for human P2X4 receptors. |
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V73583 | MRS4738 | 2801625-42-1 | MRS4738 is a potent, high-affinity P2Y14R antagonist. |
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V51678 | NF-279 | 202983-32-2 | NF279 is a potent reversible coupling inhibitor of P2X1 coupling with IC50 of 19 nM. |
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V73560 | NF023 hexasodium | 104869-31-0 | NF023 hexasodium is a selective and competitive P2X1 receptor antagonist (inhibitor) with IC50s of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2 and P2X4 respectively. |
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V73574 | NF110 | 111150-22-2 | NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and is inactive against stably expressed P2Y receptors (IC50s > 10 M). |
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V73568 | NP-1815-PX | 1239578-79-0 | NP-1815-PX is a potent and specific P2X4R antagonist. |
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V73556 | NP-1815-PX sodium | 1239578-80-3 | NP-1815-PX sodium is a potent and specific P2X4R antagonist. |
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V80213 | P2X receptor-1 | P2X receptor-1 is a potential P2X receptor blocker/inhibitor used to study pain and inflammation. | |
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V73569 | P2X2/3 modulator-1 | 1217483-98-1 | P2X2/3 modulator-1 (compound 46) is a P2X2/3 modulator. |
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V73573 | P2X3 antagonist 36 | 2310263-59-1 | P2X3 antagonist 36 is a P2X3 antagonist. |
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V73571 | P2X3 antagonist 37 | 2649318-40-9 | P2X3 antagonist 37 is a potent P2X3 receptor blocker (antagonist) with IC50 of 32.45 nM for hP2X3 (WO2021115225A1, example 68). |
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V73580 | P2X3 antagonist 38 | 2545974-71-6 | P2X3 Antagonist 38 (compound 4) is a potent and orally bioactive P2X3 antagonist (inhibitor) with IC50s of 0.132, 0.165 and 0.421 µM for hP2X3, rP2X3 and gpP2X3 respectively. |
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V73555 | P2X3-IN-1 | 2823331-49-1 | P2X3-IN-1 (example 7) is an inhibitor (blocker/antagonist) of the P2X3 receptor. |
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V73567 | P2X7 receptor antagonist-3 | 1627900-92-8 | P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist (inhibitor) with P2X7R IC50s of 4.2 nM and 6.8 nM in humans and rats respectively. |
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V73576 | Purotoxin 1 | 1396322-38-5 | Purotoxin 1 is a P2X3 receptor blocker/inhibitor. |
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V3327 | RO-3 | 1026582-88-6 | RO-3 is potent, selective, orally active and brain penetrant antagonist of homomeric P2X3and heteromeric P2X2/3receptor with pIC50values are 7.0 and 5.9 respectively. |
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V73579 | Ro-51 | 1050670-85-3 | Ro-51 is a highly efficient and selective P2X3/P2X2/3 dual antagonist, with IC50s of 2 nM and 5 nM for P2X3 and P2X2/3 respectively. |
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V73564 | Sivopixant (S-600918) | 2414285-40-6 | Sivopixant (S-600918) is a potent and specific P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). |
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V73577 | α,β-Methylene-ATP | 7292-42-4 | α,β-Methylene ATP is a phosphonate analog of ATP and a ligand for P2X3 and P2X7 receptors. |
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V73566 | α,β-Methylene-ATP dilithium | 104809-20-3 | α,β-Methylene ATP dilithium is a phosphonate analog of ATP and a ligand for P2X3 and P2X7 receptors. |
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