| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
|
| Targets |
Sodium oleate targets various cellular processes. Oleic acid, the active form, is a key component of cell membranes and plays a role in cell signaling. It has been shown to inhibit collagen-stimulated platelet aggregation by approximately 90% at a concentration of 10 µg/ml. It can modulate membrane fluidity, influence the activity of membrane-bound enzymes, and affect the production of lipid mediators.
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|---|---|
| ln Vitro |
The most prevalent monounsaturated fertilizer (FA) in human fat cells and other tissues is oleic acid. In organs with high migration rates, oleic acid stimulates AMPK oil activation-mediated beta-oxidation, which in turn drives cell division and migration. Growth and death rates of low-proliferative tumors, including the MCF-7 cell line for breast cancer and the acid blocker SGC7901 [1].
In vitro, sodium oleate is used to study the effects of fatty acids on cells. It can be used to induce cellular stress, such as lipotoxicity, or to model the effects of fatty acid overload. It inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 µg/ml. Its surfactant properties make it useful for studying membrane interactions. |
| ln Vivo |
In vivo, sodium oleate is used in research to study fatty acid metabolism and its role in various diseases. It can be administered to animal models to study the effects of oleic acid on metabolism, inflammation, and cardiovascular function. It is also used in veterinary medicine and as an emulsifier in various applications.
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| Enzyme Assay |
The biological activity of sodium oleate is assessed using various in vitro assays. Its effect on platelet aggregation is measured using aggregometry, where platelets are treated with sodium oleate and then stimulated with collagen. Its effect on cell viability and metabolism can be assessed in cell culture models. Its surfactant properties are characterized by its critical micelle concentration (CMC).
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| Cell Assay |
The cellular activity of sodium oleate is evaluated in various cell types, including platelets, hepatocytes, and adipocytes. Cells are treated with sodium oleate, and its effect on cell signaling, metabolism, and viability is assessed. Its ability to induce lipotoxicity or to modulate lipid metabolism can be studied in relevant cell models.
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| Animal Protocol |
In animal studies, sodium oleate is typically administered orally or via injection. In models of fatty liver disease, it can be used to induce hepatic steatosis. Its effect on lipid metabolism, inflammation, and cardiovascular function is assessed. Its use as an emulsifier in veterinary medicine and other applications is also studied.
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| ADME/Pharmacokinetics |
Sodium oleate has a molecular weight of 304.44 g/mol and a chemical formula of C18H33NaO2. It is a white to light yellow powder with a slight tallow-like odor. It is soluble in about 10 parts of water and about 20 parts of ethanol, and it is insoluble in benzene and ether. Its aqueous solutions are alkaline due to hydrolysis.
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| Toxicity/Toxicokinetics |
The toxicity profile of sodium oleate is related to its surfactant properties and its effects on cell membranes. At high concentrations, it can cause cell lysis. It is generally considered safe for its intended uses, but appropriate safety precautions should be taken when handling it.
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| References |
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| Additional Infomation |
Sodium oleate is a light brown solid with a slightly buttery smell. It sinks to the bottom of water and mixes slowly. (US Coast Guard, 1999) Sodium oleate is an organic molecular entity.
Sodium oleate (CAS: 143-19-1) is a widely used research reagent and industrial chemical. Its role as a surfactant and emulsifier makes it valuable in various applications, including ore flotation, textile waterproofing, and metal polishes. In research, it is a key tool for studying fatty acid biology, membrane function, and cell signaling. |
| Molecular Formula |
C18H33NAO2
|
|---|---|
| Molecular Weight |
304.443
|
| Exact Mass |
304.237
|
| CAS # |
143-19-1
|
| Related CAS # |
Oleic acid;112-80-1
|
| PubChem CID |
23665730
|
| Appearance |
White to off-white solid powder
|
| Density |
0.9 g/cm3
|
| Boiling Point |
359.999ºC at 760 mmHg
|
| Melting Point |
232-235 °C(lit.)
|
| Flash Point |
270.099ºC
|
| LogP |
4.773
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
15
|
| Heavy Atom Count |
21
|
| Complexity |
239
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CCCCCCCC/C=C\CCCCCCCC(=O)[O-].[Na+]
|
| InChi Key |
BCKXLBQYZLBQEK-KVVVOXFISA-M
|
| InChi Code |
InChI=1S/C18H34O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h9-10H,2-8,11-17H2,1H3,(H,19,20);/q;+1/p-1/b10-9-;
|
| Chemical Name |
sodium;(Z)-octadec-9-enoate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~25 mg/mL (~82.12 mM)
DMSO :< 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 9.09 mg/mL (29.86 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2847 mL | 16.4236 mL | 32.8472 mL | |
| 5 mM | 0.6569 mL | 3.2847 mL | 6.5694 mL | |
| 10 mM | 0.3285 mL | 1.6424 mL | 3.2847 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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