| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
(RS)-AMPA monohydrate (10-3-10-4 M) causes the brainstem and spinal cord of cultivated rats to become depolarized. Although the effects of (RS)-AMPA monohydrate on depolarization differ greatly amongst neurons, it appears that the effects are dose-dependent. Applying (RS)-AMPA monohydrate at 10-5 M resulted in a very little depolarization (3–7 mV), however at 10–4 M, the depolarization's magnitude varied from 4–33 mV. The rate at which spontaneously firing neurons fire is also increased by (RS)-AMPA monohydrate, and quiet cells occasionally have short action potential bursts. Without impacting NMDA receptors, (RS)-AMPA monohydrate depolarizes the body by activating glutamate/quilamate receptors [1].
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| References |
[1]. Hösli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36(1):59-62.
[2]. Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249(4976):1580-5. |
| Molecular Formula |
C7H12N2O5
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|---|---|
| Molecular Weight |
204.18
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| CAS # |
76463-67-7
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| Related CAS # |
(S)-AMPA;83643-88-3;(RS)-AMPA;77521-29-0;(RS)-AMPA hydrobromide;171259-81-7
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| SMILES |
O1C(C)=C(C(N1)=O)CC(C(=O)O)N.O
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| Solubility (In Vitro) |
H2O: 5 mg/mL (24.49 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 7.14 mg/mL (34.97 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8976 mL | 24.4882 mL | 48.9764 mL | |
| 5 mM | 0.9795 mL | 4.8976 mL | 9.7953 mL | |
| 10 mM | 0.4898 mL | 2.4488 mL | 4.8976 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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