The entire mammalian body expresses a special class of binding sites known as sigma receptors (subtypes sigma-1 and sigma-2). Although the endogenous ligand for these sites has not been discovered, N,N-dimethyltryptamine, sphingolipid-derived amines, and steroid hormones—especially progesterone—can bind with a fair amount of affinity.
The sigma-1 receptor (1R) is a chaperone protein that resides in the endoplasmic reticulum (ER) and functions as a modulator of inter-organelle signaling. Numerous biological processes, such as nociception, cancer, stroke, memory, drug addiction, cardiac activity, and Alzheimer's disease, are affected by it. Numerous human tumors have an overexpression of the sigma-2 (2R) receptor. It has been proven to be a reliable biomarker for spreading tumors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V78792 | Sigma-1 receptor antagonist 5 | 2952808-33-0 | Sigma-1 receptor antagonist 5 (compound 12) is a 4-pyridine analogue with analgesic activity and a sigma receptor (Ki=4.5 nM (σ1R), 10 nM (σ2R)) and histamine H3 (hH3R, Ki= 7.7 nM, IC50=215 nM) antagonist. |
|
V70046 | Sigma-2 Radioligand 1 | 2860554-32-9 | Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. |
|
V86295 | SOMCL-668 | 1422251-09-9 | |
|
V71970 | Tetrahydroamentoflavone (Amentoflavone) | 48236-96-0 | Tetrahydroamentoflavanone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. |
|
V71968 | Tigulixostat (LC350189) | 1287766-55-5 | Tigulixostat (LC350189) is an orally bioactive, non-purine-selective xanthine oxidase inhibitor. |
|
V70039 | WLB-89462 | 2849471-75-4 | WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). |
|
V71971 | Xanthine oxidase-IN-10 | 851429-65-7 | Xanthine oxidase-IN-10 (XO8 analog) is a xanthine oxidase (XO) inhibitor. |
|
V71986 | Xanthine oxidoreductase-IN-3 | 651769-78-7 | Xanthine oxidoreductase-IN-3 is an orally bioactive xanthine oxidoreductase (XOR) inhibitor (antagonist) with IC50 of 26.3 nM. |
|
V70031 | σ1 Receptor antagonist-1 | 1204401-49-9 | σ1 Receptor antagonist-1 is a highly efficient and selective sigma 1 receptor antagonist (pKi=10.28). |
|
V30747 | Dimemorfan phosphate | 36304-84-4 | Dimemorfan phosphate (Astomin; AT17; Gentus; AT-17) is a morphinan-based sigma 1 receptor agonistwith potent antitussive activity. |
|
V0097 | Cutamesine (SA 4503; AGY 94806) | 165377-43-5 | Cutamesine (SA-4503; AGY-94806) is a selective and potent sigma-1 (σ1) receptor agonist with an IC50of 17.4 nM in guinea pig brain membranes, 100-fold less selective for the sigma 2 receptor. |
|
V2813 | Cutamesine (SA-4503) dihydrochloride | 165377-44-6 | SA4503 dihydrochloride (also known asAGY94806 dihydrochloride andCutamesine dihydrochloride), is a potent sigma-1 (σ1) receptor agonist with an IC50of 17.4 nM in guinea pig brain membranes. |
|
V27982 | Vesamicol hydrochloride, (+/-)- | 120447-62-3 | (±)-Vesamicol HCl ((±)-AH5183 HCl) is a potent inhibitor of vesicular acetylcholine transport with Ki of 2 nM. |
|
V3703 | Siramesine | 147817-50-3 | Siramesine (Formerly known as Lu-28-179) is a potent and selective agonist of sigma-2 receptor. |
|
V2908 | Siramesine HCl | 224177-60-0 | Formerly known as Lu-28-179, siramesine HCl is a potent and selective sigma-2 receptor agonist with anticancer effects. |
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