| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| Other Sizes |
| ln Vitro |
MO-I-1100 has no effect on the viability of NIH3T3 cells lacking ASPH on the cell surface [1]. MO-I-1100 (1-10 μM) inhibits the viability of FOCUS cells, which have high levels of ASPH expression [1].
|
|---|---|
| ln Vivo |
MO-I-100 (50 mg/kg, ip, 5 days per week for 2 weeks, then every other day) reduces tumor growth in an intrahepatic orthotopic xenograft HCC model [1]. MO-I-1100 (50 mg/kg/day, ip, for 5 days) reduces activated Notch 1 (cleaved fragment) and downstream HES1 and HEY1 gene expression [1].
|
| Animal Protocol |
Animal/Disease Models: Nude mice with established s.c. tumor xenografts of FOCUS cells[1]
Doses: 50 mg/kg/day Route of Administration: Ip, for 5 days Experimental Results: Reduced the activated Notch 1 (cleaved fragment) as well as downstream HES1 and HEY1 gene expression. |
| References |
| Molecular Formula |
C17H14CLNO5S
|
|---|---|
| Molecular Weight |
379.81
|
| CAS # |
1585217-40-8
|
| Appearance |
White to off-white solid
|
| SMILES |
O=C1C(OS(CC2=CC=CC=C2)(=O)=O)=C(N)OC1C3=CC=C(Cl)C=C3
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ~15 mg/mL (~39.5 mM; with ultrasonication and warming by heating to 60°C)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.5 mg/mL (3.95 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (15.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6329 mL | 13.1645 mL | 26.3290 mL | |
| 5 mM | 0.5266 mL | 2.6329 mL | 5.2658 mL | |
| 10 mM | 0.2633 mL | 1.3164 mL | 2.6329 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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