A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70684 | Chrysophanol-1-O-β-gentiobioside (Chrysophanol-1-O-β-gentiobioside) | 54944-38-6 | Chrysophanol-1-O-β-gentiobioside, an anthraquinone glycoside extracted from Cassia seeds. |
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V99873 | COMT-IN-1 | 2987884-27-3 | COMT-IN-1 (Compound C12), a nitrophenol analog, is an orally active catechol-O-methyltransferase (COMT) inhibitor with IC50 of 0.37 μM, 95.58 μM, and 58.82 μM for COMT, MAO-A, and MAO-B, respectively. |
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V70668 | Decaffeoylacteoside (Decaffeoylverbascoside; Verbasoside) | 61548-34-3 | Decaffeoylacteoside is an inhibitor (blocker/antagonist) of AChE/BChE/LOX with moderate activity. |
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V107552 | DOPR hydrochloride | 53581-55-8 | DOPR hydrochloride is a psychoactive substance of the amphetamine class. |
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V70669 | Echitovenidine | 7222-35-7 | Echitovenidine is an alkaloid extracted from Alstonia yunnanensis. |
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V70670 | ETAP | 2575731-47-2 | ETAP is an MAO-A and MAO-B inhibitor. |
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V70677 | Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate | 28705-46-6 | Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate is a potent hMAO-B selective inhibitor (antagonist) with IC50 of 45.52 μM. |
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V67662 | Glicoricone | 161099-37-2 | Glicoricone is a phenolic compound extracted from licorice. |
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V76938 | Harmane-d (Harmane-d1) | Harmane-d is the deuterium labelled form of Harmane. | |
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V79700 | Harmane-d2 (Harmane-d2) | Harmane-d2 is the deuterium labelled form of Harmane. | |
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V85743 | hMAO-A-IN-1 | 1039315-88-2 | |
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V104236 | hMAO-B-IN-10 | hMAO-B-IN-10 (Compound 7) is an inhibitor of MAO-A/B with IC50 of 424.1 nM and 177.9 nM, respectively. | |
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V70654 | hMAO-B-IN-5 | 358343-63-2 | hMAO-B-IN-5(B15) is a specific and reversible inhibitor of human monoamine oxidase hMAO-B with IC50 of 0.12 μM. |
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V85813 | hMAO-B-IN-6 | 2764830-43-3 | |
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V85425 | hMAO-B-IN-7 | 2955577-14-5 | |
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V70661 | hMAO-B/MB-COMT-IN-1 | 254974-70-4 | hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC50s: hMAO-B is 2.5 μM, MB-COMT is 3.84 μM). |
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V70679 | Homopterocarpin ((-)-Homopterocarpin; 3,9-Dimethoxypterocarpan) | 606-91-7 | Homopterocarpin is an isoflavone that can be extracted from Pterocarpus erinaceus. |
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V70658 | Hydroxylamine-d3 hydrochloride (hydroxylamine hydrochloride-d3; hydroxylamine hydrochloride-d3) | 15588-23-5 | Hydroxylamine-d3 ( HCl) is the deuterated form of Hydroxyamine HCl. |
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V80226 | IHC3 | IHC3 is a competitive and reversible inhibitor of MAO-B (IC50= 1.672 μM). | |
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V22802 | J147 | 1146963-51-0 | J147 is a potent neuroprotective and neurotrophic compound. |
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