A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V128153 | AChE/MAO-B-IN-8 | AChE/MAO-B-IN-8 is an inhibitor of acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), with IC50 values of 0.72 μM and 0.19 μM, respectively. | |
|
V70640 | Aminoacetone hydrochloride | 7737-17-9 | Aminoacetone HCl is the simplest single peptide. |
|
V78050 | Antioxidant agent-13 | 2966778-87-8 | Antioxidant agent-13 (Compound 5f) is an antioxidant. |
|
V87818 | Bazinaprine | 94011-82-2 | Bazinaprine (SR 95191) is a derivative of minaprine and an orally active monoamine oxidase type A (MAO) inhibitor. |
|
V119767 | BChE/MAO-B-IN-2 | BChE/MAO-B-IN-2 is a dual inhibitor of BChE (IC50 = 0.05 μM, Ki = 0.01 μM) and MAO-B (IC50 = 0.45 μM, Ki = 0.08 μM) with good blood-brain barrier permeability. | |
|
V111067 | Benzylhydrazine | 555-96-4 | Benzylhydrazine is a potent monoamine oxidase (MAO) inhibitor. |
|
V103853 | C175-0062 | 686736-69-6 | C175-0062 is a monoamine oxidase B (MAO-B) inhibitor. |
|
V85269 | ChEs/MAOs-IN-1 | ||
|
V70684 | Chrysophanol-1-O-β-gentiobioside (Chrysophanol-1-O-β-gentiobioside) | 54944-38-6 | Chrysophanol-1-O-β-gentiobioside, an anthraquinone glycoside extracted from Cassia seeds. |
|
V99873 | COMT-IN-1 | 2987884-27-3 | COMT-IN-1 (Compound C12), a nitrophenol analog, is an orally active catechol-O-methyltransferase (COMT) inhibitor with IC50 of 0.37 μM, 95.58 μM, and 58.82 μM for COMT, MAO-A, and MAO-B, respectively. |
|
V70668 | Decaffeoylacteoside (Decaffeoylverbascoside; Verbasoside) | 61548-34-3 | Decaffeoylacteoside is an inhibitor (blocker/antagonist) of AChE/BChE/LOX with moderate activity. |
|
V133989 | DL-Thyroxine | 300-30-1 | DL-Thyroxine is a thyroid hormone and a monoamine oxidase inhibitor. |
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V107552 | DOPR hydrochloride | 53581-55-8 | DOPR hydrochloride is a psychoactive substance of the amphetamine class. |
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V70669 | Echitovenidine | 7222-35-7 | Echitovenidine is an alkaloid extracted from Alstonia yunnanensis. |
|
V70670 | ETAP | 2575731-47-2 | ETAP is an MAO-A and MAO-B inhibitor. |
|
V70677 | Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate | 28705-46-6 | Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate is a potent hMAO-B selective inhibitor (antagonist) with IC50 of 45.52 μM. |
|
V110389 | Ethyl homovanillate | 60563-13-5 | Ethyl homovanillate (compound 24) is a structural analogue of eugenol. |
|
V135814 | FCOB02 | 3064236-41-2 | FCOB02 is a monoamine oxidase B (MAO-B) ligand. |
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V136573 | Geiparvarin | 36413-91-9 | Geiparvarin is an anticancer drug and also an MAO-B inhibitor (pIC50 = 6.84 μM). |
|
V67662 | Glicoricone | 161099-37-2 | Glicoricone is a phenolic compound extracted from licorice. |
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