Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system of vertebrates, activates a group of receptors known as GABA receptors. GABAA and GABAB are the two classes of GABA receptors. GABAB receptors are G protein-coupled receptors, also known as metabotropic receptors, while GABAA receptors are ligand-gated ion channels, also known as ionotropic receptors. It has long been known that direct anion channel activation causes neurons to respond quickly to GABA, which is blocked by bicuculline and picrotoxin. The GABAA receptor is the name given to this channel later. Fast-acting GABA receptors belong to the Cys-loop ligand-gated ion channel family. GABAB receptors, originally identified based on their pharmacological properties, mediate a slow response to GABA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1934 | Oxiracetam (ISF 2522) | 62613-82-5 | Oxiracetam (also known as ISF 2522), a novel cyclic derivative of gamma-aminobutyric acid (GABA) which acts as a positive allosteric modulator of the AMPA receptors, is widely used as a nootropic drug to improve memory and learning in patients with cognitive impairments. |
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V71841 | Phaclofen | 114012-12-3 | Phaclofen is a selective GABAB receptor antagonist. |
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V71806 | Phenibut hydrochloride (β-Phenyl-GABA hydrochloride; 4-Amino-3-phenylbutanoic acid hydrochloride) | 3060-41-1 | Phenibut (β-Phenyl-GABA) HCl is an orally bioactive GABA-B agonist. |
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V10395 | Picrotoxin | 124-87-8 | Picrotoxin (cocculin) is a naturally occuring and poisonous crystalline plant compound. |
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V71843 | Piperidine-4-sulfonic acid | 72450-62-5 | Piperidine-4-sulfonic acid is a potent GABA agonist that can inhibit H-GABA binding with IC50 of 0.034 μM. |
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V70269 | Pregabalin arenacarbil | 1174748-30-1 | Pregabalin arenacarbil is the precursor of Pregabalin. |
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V83202 | Pyrazolam | 39243-02-2 | Pyrazolam is a drug belonging to the benzodiazepine class |
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V70274 | Riluzole-13C,15N2 (PK 26124-13C,15N2) | 1215552-03-6 | Riluzole-13C,15N2 is 13C (carbon 13) and 15N (nitrogen 15) labelled Riluzole. |
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V60092 | Rosmariquinone | 27210-57-7 | Miltirone is a naturally occurring compound found in salvia. |
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V71836 | SCS (Salicylidene salicylhydrazide) | 3232-36-8 | SCS (Salicylidene salicylhydraide) is a potent, allosteric, and selective inhibitor of β1-containing GABAA receptors, with IC50 of 32 nM for α2β1γ1θ as measured by VIPR. |
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V71814 | SJM-3 | 1234977-97-9 | SJM-3 is a PAM (positive allosteric modulator) of different subtypes of GABAA receptors. |
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V85162 | SKF 97541 (CGP 35024) | 127729-35-5 | |
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V71803 | TACA (trans-4-Aminocrotonic acid) | 38090-53-8 | TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABAA and GABAC receptors (KD= 0.6μM). |
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V71850 | Temgicoluril (Tetramethylglycoluril; Mebicar) | 10095-06-4 | Tetramethylglycerol (Tetramethylglycoluril) works on GABA receptors and has anxiolytic (anti-anxiety) activity. |
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V80263 | TETS-4-Methylaniline | TETS-4-Methylaniline is a hapten. | |
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V14286 | Tiagabine hydrochloride | 145821-59-6 | Tiagabine HCl (NNC-05-0328; NO-05-0328;NO329;NNC-050328;NO 329; trade name Gabitril),the hydrochloride salt of tiagabine, is an marketed anticonvulsant acting as a selective GABA (gamma-aminobutyric acid) reuptake inhibitor, may also be used for the treatment of panic disorders. |
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V71846 | TPMPA | 182485-36-5 | TPMPA, a mixture of isotetrahydronicotinic acid and 3-APMPA, is the first selective antagonist of GABAC (KB = 2.1 μM) but is not interacted with GABAA (KB = 320 μM) or GABAB (EC50 = 500 μM). |
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V71823 | U-89843A | 157013-85-9 | U-89843A is an allosteric modulator of GABAA receptors. |
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V19710 | U-93631 | 152273-12-6 | U-93631 is a GABAA receptor antagonist. |
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V71818 | Valiloxibic acid (Acidum valiloxibicum; XWL-008) | 238401-16-6 | Valiloxibic acid is the precursor active molecule of gamma-hydroxybutyric acid (GHB). |
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