Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system of vertebrates, activates a group of receptors known as GABA receptors. GABAA and GABAB are the two classes of GABA receptors. GABAB receptors are G protein-coupled receptors, also known as metabotropic receptors, while GABAA receptors are ligand-gated ion channels, also known as ionotropic receptors. It has long been known that direct anion channel activation causes neurons to respond quickly to GABA, which is blocked by bicuculline and picrotoxin. The GABAA receptor is the name given to this channel later. Fast-acting GABA receptors belong to the Cys-loop ligand-gated ion channel family. GABAB receptors, originally identified based on their pharmacological properties, mediate a slow response to GABA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70281 | Etifoxine-d5 | 1346598-10-4 | Etifoxine-d5 is the deuterated form of etifoxine. |
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V51181 | Etiocholanolone (5β-Androsterone) | 53-42-9 | Etiocholanolone (5β-Androsterone) is a testosterone excretion aid with anticonvulsant (antiepileptic/antiseizure) activity. |
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V71845 | Fengabine (SL 79229) | 80018-06-0 | Fengabine is a GABAergic antidepressant active molecule. |
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V5922 | Fluralaner (A1443; AH252723) | 864731-61-3 | Fluralaner(A-1443; AH-252723; trade name: Bravecto) is an orally bioavailable and systemic insecticide and acaricide approved by the US Food and Drug Administration (FDA) under the trade name Bravecto for flea treatment in dogs in May 2014. |
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V71847 | Furosemide-d5 (furosemide d5) | 1189482-35-6 | Furosemide-d5 is the deuterated form of Furosemide. |
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V79545 | GABA receptor Antagonist 1 | GABA receptor Antagonist 1 (compound 7w) inhibits Px RDL1 GABAR with IC50 of 7.08 nmol/L. | |
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V70277 | GABAA receptor agent 2 TFA | 1781880-44-1 | GABAA receptor agent 2 TFA is a potent high-affinity GABAA receptor antagonist (inhibitor) with IC50 of 24 nM (tsA201 cells expressing human α1β2γ2 GABAA) and a Ki of 28 nM (rat GABAA receptor). |
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V70284 | GABAB receptor antagonist 1 | 797-17-1 | GABAB receptor antagonist 1 (compound 14) is a selective NAM (negative allosteric modulator) of the GABAB (gamma-aminobutyric acid) receptor. |
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V79549 | GAD65(247-266) epitope TFA | GAD65(247-266) epitope TFA is a T cell epitope of islet antigen that competitively binds to I-Ag7 (type I diabetes-related molecule), but with poor affinity. | |
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V70290 | GBLD345 | 122479-08-7 | GBLD345 is a non-benzodiazepine anxiolytic (anti-anxiety) agent and a non-selective positive allosteric modulator (PAM) of GABAA receptors. |
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V76984 | Gidazepam-d5 (Gidasepam-d5; Hidazepam-d5; Hydazepam-d5) | Gidazepam-d5 is deuterium labeled Gidazepam. | |
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V60128 | Guvacine | 498-96-4 | Guvacine is an alkaloid found in nuts and is a potent diluent of the GABA nutrient. |
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V70287 | Guvacine ethyl ester | 18513-76-3 | Guvacine ethyl ester (3.1b) is an alkaloid found in betel nut. |
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V71829 | Guvacine hydrobromide | 6027-92-5 | Guvacine HBr is an alkaloid found in areca nut and is a potent GABA uptake inhibitor. |
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V70272 | Isohyenanchin (Hydroxycoriatin) | 19417-00-6 | Isohyenanchin (Hydroxycoriatin) is an RDLac homo-oligomers antagonist. |
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V71808 | Isonipecotic acid (4-piperidinecarboxylic acid) | 498-94-2 | Isonipecotic acid is a GABAA receptor partial agonist. |
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V71832 | Isonipecotic acid-d9 (4-piperidinecarboxylic acid-d9) | 1219798-43-2 | Isonipecotic acid-d9 is the deuterium labelled form of Isonipecotic acid. |
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V31861 | LAU159 | 2055050-87-6 | LAU159 is a functionally selective positive modulator of the α1β3 GABA(A) receptor with EC50 of 2.2 μM. |
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V71801 | Lesogaberan hydrochloride (AZD-3355 hydrochloride) | 2925644-17-1 | Lesogaberan (AZD-3355) HCl is a potent and specific GABAB receptor agonist/activator with EC50 of 8.6 nM for human recombinant GABAB receptor. |
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V70285 | Lesogaberan napadisylate (AZD-3355 napadisylate) | 477956-38-0 | Lesogaberan (AZD-3355) napadisylate is a potent and specific GABAB receptor agonist/activator with EC50 of 8.6 nM for human recombinant GABAB receptor. |
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