The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71637 | (+)-Balanophonin | 215319-47-4 | (+)-Balanophonin is a natural phenolic compound extracted from Passiflora edulis and has antioxidant, anticholinesterase, anti~inflammatory, anticancer and anti-neurodegenerative activities. |
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V71626 | (R)-Donepezil ((R)-Donepezil; (R)-E2020 free base) | 142698-19-9 | (R)-Donepezil is the R-enantiomer of Donepezil . |
|
V71649 | (rac)-Rivastigmine-d6 (rivastigmine d6) | 194930-04-6 | (rac)-Rivastigmine-d6 is the deuterated racemate of Rivastigmine. |
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V71697 | (Rac)-Sclerone | 19638-58-5 | (Rac)-Sclerone is a naturally occurring compound that can be extracted from the green shell of pecans. |
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V101850 | (Rac)-TZ3O | 2218754-19-7 | (Rac)-TZ3O is the (Rac) isomer of TZ3O. |
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V71614 | (S)-Donepezil ((S)-E2020 free base) | 142057-80-5 | (S)-Donepezil is the R-enantiomer of Donepezil. |
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V97126 | (S)-Ladostigil | 209394-29-6 | (S)-Ladostigil (TV-3279) is the S-enantiomer of TV 3326, a ChE inhibitor with weak inhibitory activity against MAO-B. |
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V71615 | (±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) | 2504-11-2 | (±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) is a weak cholinergic agonist/activator with cholinergic properties. |
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V106966 | 1,10-Bis(pyridinium)decane | 6266-40-6 | |
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V103718 | 1,2-Didehydrotanshinone IIA | 119963-50-7 | |
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V71645 | 2'-O-Succinyl-cAMP | 36940-87-1 | 2'-O-Succinyl-cAMP, a cAMP analog, can be covalently coupled to acetylcholinesterase. |
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V71631 | 3β-Hydroxy-lup-20(29)-en-16-one | 65043-60-9 | 3β-Hydroxy-lup-20(29)-en-16-one (compound 9) is a dual (bifunctional) inhibitor of AChE and BChE, with selectivity for BChE (IC50= 28.9 μM). |
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V105589 | 4-Hydroxyisophthalic acid | 636-46-4 | |
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V71651 | 4-Methylbenzylidene camphor-d4 | 1219806-41-3 | 4-Methylbenzylidene camphor-d4 is the deuterated form of 4-Methylbenzylidene camphor. |
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V106754 | 6,9-Dichloro-1,2,3,4-tetrahydroacridine | 5396-25-8 | |
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V71630 | 7-Acetoxy-1-methylquinolinium iodide (AMQI) | 7270-83-9 | 7-Acetoxy-1-methylquinolinium iodide (AMQI) is a fluorescent substrate for cholinesterase (Ex = 320 nm, Em = 410 nm). |
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V71679 | Acacetin-7-O-β-D-galactopyranoside | 80443-15-8 | Acacetin-7-O-β-D-galactopyranoside is a flavonoid that can be extracted from the flower heads of Chrysanthemum morifolium. |
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V71681 | Acephate (acephate; acephate) | 30560-19-1 | Acephate is a broad-spectrum anticholinesterase insecticide. |
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V71613 | Acetylcholinesterase (ACHE; EC 3.1.1.7) | 9000-81-1 | Acetylcholinesterase (ACHE; EC 3.1.1.7), acetylcholinesterase, is a cholinergic enzyme that mainly exists in neuromuscular junctions and cholinergic type chemical synapses and is widely utilized in biochemical research. |
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V71690 | AChE-IN-10 | 2770832-90-9 | AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE (IC50 = 2.4 nM). |
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