The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71691 | Territrem B | 70407-20-4 | Territrem B is an irreversible inhibitor of acetylcholinesterase (AChE). |
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V117700 | Territrem C | 89020-33-7 | Territrem C is an acetylcholinesterase (AChE) inhibitor with an IC50 of 0.23 μM. |
|
V101093 | Tl45b | Tl45b is an inhibitor of AChE with IC50 of 0.71 μM. | |
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V92437 | Trimedoxime | 56-97-3 | Trimedoxime (TMB-4) has the ability to induce oxidative stress with an IC50 of 22 mM. |
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V111132 | Trimethidinium methosulfate | 14149-43-0 | Trimethylammonium methyl sulfate is an orally effective ganglion blocker with central hypotensive effects. |
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V80023 | TZ3O | TZ3O (compound TZ30) is an anticholinergic agent with neuro-protection effects. | |
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V79960 | TZ4M | TZ4M is a 2,4-thiazolidinedione (TZD)-based anti-AD agent with neuro-protection effects. | |
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V71612 | Velnacrine maleate (HP 029; Hydroxytacrine maleate) | 118909-22-1 | Velnacrine maleate (HP 029) is an orally bioactive cholinesterase inhibitor that may be utilized in Alzheimer's disease (AD) research. |
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V92295 | VU0366369 | 1222834-53-8 | VU0366369 (ML137) is a selective positive allosteric modulator (PAM) of mAChR M1 with EC50 of 830 nM. |
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V71692 | Xanthohumol I | 688360-06-7 | Xanthohumol I is a chalcone, an analogue of Xanthohumol. |
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V76342 | Y13g dihydrochloride | Y13g di-HCl is a potent inhibitor of AChE and IL-6. | |
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V71706 | Z164597606 | 1050587-57-9 | Z164597606 is a selective BChE inhibitor (IC50= 1.3 and 1.7 μM for eqBChE and hBChE, respectively). |
|
V87793 | Z32439948 | 920845-86-9 | Z32439948 is a butyrylcholinesterase (BChE) inhibitor (IC50: 1.4 μM, hBChE), a derivative of m-sulfamoylbenzamide. |
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V87790 | Zanapezil | 142852-51-5 | Zanapezil (TAK-147) is a potent, reversible and selective acetylcholinesterase (AChE) inhibitor. |
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V71625 | Zanapezil free base (TAK-147 free base) | 142852-50-4 | Zanapezil (TAK-147) free base is a potent, reversible and selective inhibitor of acetylcholinesterase (AChE). |
|
V114326 | Zifrosilone | 132236-18-1 | Zifrosilone is an orally effective acetylcholinesterase (AChE) inhibitor with a mean maximum inhibition rate of 20.9% at a 10 mg dose. |
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V71678 | α-NETA | 115066-04-1 | α-NETA is a potent, noncompetitive inhibitor of choline acetyltransferase (ChA) with IC50 of 9 μM. |
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V28743 | Scopoletin (Gelseminic acid; Chrysatropic acid) | 92-61-5 | Scopoletin is an acetylcholinesterase (AChE) inhibitor. |
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V30596 | Violanthin | 40581-17-7 | Violanthin is a naturally occuring flavanoid 8-c-glycoside acting as apotent acetylcholinesterase (AChE) inhibitor with IC50 of 79.80 μM. |
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V33475 | Rivastigmine | 123441-03-2 | Rivastigmine, also known as ENA-713 and SDZ-ENA 713, is a reversible cholinesterase inhibitor with IC50 of 5.5 μM,it isused as a parasympathomimetic or cholinergic agent for the management of mild to moderate Alzheimer disease, Dementia, and Parkinson's Disease. |
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