| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
|
||
| 100mg |
|
||
| 250mg |
|
||
| 500mg |
|
||
| Other Sizes |
|
| ln Vitro |
One potential earphonetic cholinesterase (AChE) was found to be scopoletin (SCT). Scopoletin suppresses PC3 proliferation by stimulating PC3 cells. It stimulates K+-stimulated ACh release from frontal lobe synaptosomes, displaying a bell-shaped dose-response curve (Emax: 4 μM) [1]. Scopolamine's IC50 values for PC3, PAA (human lung cancer cells), and HeLa cells are (157±25), (154±51), and (294±100) mg/L, in that order. In PC3 cells, scopeoline significantly inhibits apoptosis in a time- and concentration-dependent manner. In PC3 cells, scopolamine decreased protein content and acid phosphatase activity (ACP) levels in a concentration-dependent way. Using scopolamine at 0, 100, 200, and 400 mg/L, the cell disinfection rates were found to be 0.3%, 2.1%, 9.3%, and 35% by light, fluorescence, and brightness electron microscopy, respectively. cells, displaying the common morphological modifications brought up by cell sterilizing. There is a marked decrease in the number of cells in the G2 phase [2].
|
|---|---|
| ln Vivo |
In scopolamine-induced cholinergic-deficient probes, scopolamine (2 μg, icv) improves novel object identification and promotes T-maze alternation. In addition, scopolamine (2 mg/kg sc) improves object memory deficiencies associated with age in probes aged 15–18 months. An increase in alternation rate of 71.3±2.5% was seen in mice treated with 2 μg of scopolamine [1].
|
| ADME/Pharmacokinetics |
Metabolism / Metabolites
Scopoletin has known human metabolites that include Scopoletin hydroxy-glucuronide. |
| References |
|
| Additional Infomation |
Scopoletin is a hydroxycoumarin that is umbelliferone bearing a methoxy substituent at position 6. It has a role as a plant growth regulator and a plant metabolite. It is functionally related to an umbelliferone.
Scopoletin has been reported in Caragana frutex, Phyllanthus sellowianus, and other organisms with data available. Scopoletin is a coumarin compound found in several plants including those in the genus Scopolia and the genus Brunfelsia, as well as chicory (Cichorium), redstem wormwood (Artemisia scoparia), stinging nettle (Urtica dioica), passion flower (Passiflora), noni (Morinda citrifolia fruit) and European black nightshade (Solanum nigrum) that is comprised of umbelliferone with a methoxy group substituent at position 6. Scopoletin is used to standardize and establish pharmacokinetic properties for products derived from the plants that produce it, such as noni extract. Although the mechanism(s) of action have not yet been established, this agent has potential antineoplastic, antidopaminergic, antioxidant, anti-inflammatory and anticholinesterase effects. Plant growth factor derived from the root of Scopolia carniolica or Scopolia japonica. See also: Arnica montana Flower (part of); Lycium barbarum fruit (part of); Viburnum opulus root (part of). |
| Molecular Formula |
C10H8O4
|
|---|---|
| Molecular Weight |
192.1681
|
| Exact Mass |
192.042
|
| CAS # |
92-61-5
|
| PubChem CID |
5280460
|
| Appearance |
White to yellow solid powder
|
| Density |
1.4±0.1 g/cm3
|
| Boiling Point |
413.5±45.0 °C at 760 mmHg
|
| Melting Point |
203-205 °C(lit.)
|
| Flash Point |
172.4±22.2 °C
|
| Vapour Pressure |
0.0±1.0 mmHg at 25°C
|
| Index of Refraction |
1.609
|
| LogP |
1.28
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
14
|
| Complexity |
261
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
RODXRVNMMDRFIK-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C10H8O4/c1-13-9-4-6-2-3-10(12)14-8(6)5-7(9)11/h2-5,11H,1H3
|
| Chemical Name |
7-hydroxy-6-methoxychromen-2-one
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~62.5 mg/mL (~325.23 mM)
Ethanol :< 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (10.82 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.08 mg/mL (10.82 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (10.82 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.2037 mL | 26.0186 mL | 52.0373 mL | |
| 5 mM | 1.0407 mL | 5.2037 mL | 10.4075 mL | |
| 10 mM | 0.5204 mL | 2.6019 mL | 5.2037 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
