It has been established that the Ca2+/calmodulin-dependent kinase (CaMK) family is an important mediator in living things and numerous biological processes.
CaMK II is a multifunctional protein kinase that phosphorylates and modifies the function of a wide range of substrates in the cytoplasm in response to calcium and calmodulin. It has been discovered that the cAMP-response element binding protein (CREB) pathway controls the RANKL-induced osteoclast formation through the CaMK II pathway.
Intracellular calciumol/L has been repeatedly shown to be crucial among the many signaling pathways of proliferation. Calciumol/L activates the CaMKs, a family of structurally related serine/threonine protein kinases, including CaMKI-IV, in the cytoplasm by binding to calmodulin. Cell cycle, apoptosis, gene expression, and neurotransmission are just a few of the physiological processes that CaMKII, a multifunctional protein kinase, is constantly involved in.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71546 | Ph-HTBA | 2368927-41-5 | Ph-HTBA is a high-affinity, brain-penetrating modulator of CaMKIIα. |
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V2702 | STO-609 | 52029-86-4 | STO-609 is a novel, potent, specific and cell-permeable inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms with Ki values of 80 and 15 ng/ml, respectively, it also inhibits their autophosphorylation activities. |
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V76460 | Syntide 2 TFA | Syntide 2 (TFA) is a Ca2+ and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide that selectively inhibits gibberellin (GA) responses, leaving constitutive and abscisic acid regulatory events unaffected . | |
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V71548 | TIM-063 | 2493978-38-2 | TIM-063 is a selective and cell-permeable (penetrable) CaMKK inhibitor, an ATP competitive inhibitor that can directly target the catalytic domain of CaMKK. |
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