Melanocortin Receptor

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Melanocortin Receptor

The different subtypes of the melanocortin (MC) receptors, which are a subfamily of G-protein-coupled receptors (GPCRs), play a variety of physiological roles, including pigmentation, steroid secretion, energy homeostasis, and food intake. Five G-protein-coupled receptors (MC1R-MC5R) make up the melanocortin receptor (MCR) family. The MC1R regulates pigmentation, the MC2R is an essential part of the hypothalamic-pituitary-adrenal axis, the MC3R, MC4R, and MC5R are involved in exocrine function, and they all play a significant role in energy homeostasis.

A number of neuropeptides known as melanocortins, such as adrenocorticotropic hormone (ACTH) and,, and -melanocyte-stimulating hormones (MSHs), activate MCRs. Pro-opiomelanocortin, a common polypeptide precursor that is primarily expressed in the hypothalamus and pituitary, is processed post-translationally to produce melanocortins.

Melanocortin Receptor related products

Cat No.	Product Name	CAS No.	Product Description
V70585	Chlorophorin	537-41-7	Chlorophorin is an inhibitor (blocker/antagonist) of the Melanocortin Receptor.
V86663	CRN04894	2392970-97-5	CRN04894 (compound 17h) is an orally active MC2R antagonist that exhibits in vivo efficacy in a rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion.
V94273	Dersimelagon phosphate	2490660-87-0	Dersimelagon phosphate is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14, and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m), and rat (r) MC1R, respectively.
V79400	Fenoprofen-13C6 sodium hydrate (Fenoprofen 13C6)		Fenoprofen-13C6 (sodium hydrate) is 13C (carbon 13) labelled Fenoprofen.
V88930	GPS1573	2445822-54-6	GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-stimulated MC2R activity (IC50=66 nM).
V76917	HS014 TFA		HS014 TFA is a potent and specific melanocortin-4 (MC4) receptor antagonist (inhibitor) with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively.
V76916	HS024 TFA		HS024 is a selective MC4 receptor antagonist (inhibitor) with Ki of 0.29, 3.29, 5.45 and 18.6 nM for MC4, MC5, MC3 and MC1 respectively.
V70577	IIIM-8	1128053-62-2	IIIM-8 is a melanin production inhibitor.
V70581	JKC363	436083-30-6	JKC363 is a selective melanocortin MC4 receptor antagonist, with an affinity 90 times higher at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM).
V80448	JKC363 TFA		JKC363 TFA is a selective melanocortin MC4 receptor antagonist, with 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM).
V4507	JNJ-10229570	524923-88-4	JNJ-10229570 is a novel, potent and selective antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R) with the potential to treat primary human sebaceous cells and for the treatment of acne and other sebaceous gland pathologies.
V70574	Lys-γ3-MSH(human)	156159-18-1	Lys-γ3-MSH (human) is a melanocortin peptide extracted from the C-terminus of the POMC fragment.
V80654	Lys-γ3-MSH(human) TFA		Lys-γ3-MSH (human) TFA is a melanocortin peptide extracted from the C-terminus of the POMC fragment.
V70583	MCL0020	475498-26-1	MCL0020 is a potent and specific melanocortin MC4 receptor antagonist (inhibitor) with IC50 of 11.63 nM.
V86667	Melanostatin, frog	134709-16-3	Melanostatin, frog is an inhibitor of α-melanocyte stimulating hormone (α-MSH) release with IC50 of 60 nM.
V70568	ML-00253764 hydrochloride	1706524-94-8	ML-00253764 is a non-peptide melanocortin receptor 4 (MC4R) antagonist (inhibitor) with Ki and IC50s of 0.16 µM and 0.103 µM, respectively.
V70564	ML00253764	681847-92-7	ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist that can cause apoptosis by inhibiting ERK1/2 and Akt phosphorylation and has anti-neoplastic activity.
V70566	MSG606	1416983-77-1	MSG606 is a selective MC1R (melanocortin 1 receptor) antagonist that may be utilized to study neuro-protective (neuro-protection) effects.
V80844	MSG606 TFA		MSG606 TFA is a potent human MC1 receptor antagonist (IC50=17 nM).
V70569	N,N′-Diferuloylputrescine	42369-86-8	N,N′-Diferuloylputrescine is an inhibitor (blocker/antagonist) of pigmentation and reduced pigmentation by 57%.