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    JNJ-10229570
    JNJ-10229570

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V4507
    CAS #: 524923-88-4Purity ≥98%

    Description: JNJ-10229570 is a novel, potent and selective antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R) with the potential to treat primary human sebaceous cells and for the treatment of acne and other sebaceous gland pathologies. JNJ-10229570 inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.

    References: J Dermatol Sci. 2011 Jul;63(1):23-32.


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    JNJ-10229570

    Name: JNJ-10229570
    CAS#: 524923-88-4
    Chemical Formula: C22H19N3O2S
    Exact Mass: 389.1198
    Molecular Weight: 389.47
    Elemental Analysis: C, 67.84; H, 4.92; N, 10.79; O, 8.22; S, 8.23
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: JNJ-10229570; JNJ10229570; JNJ 10229570; UNII-N9IX402L35.
    IUPAC/Chemical Name: Benzenamine, N-(2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene)-
    InChi Key: XTHRTBCPBWJYRO-GHVJWSGMSA-N
    InChi Code: InChI=1S/C22H19N3O2S/c1-26-19-14-8-6-12-17(19)21-24-22(23-16-10-4-3-5-11-16)28-25(21)18-13-7-9-15-20(18)27-2/h3-15H,1-2H3/b23-22+
    SMILES Code: COC1=CC=CC=C1C2=N/C(SN2C3=CC=CC=C3OC)=N\C4=CC=CC=C4


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