The different subtypes of the melanocortin (MC) receptors, which are a subfamily of G-protein-coupled receptors (GPCRs), play a variety of physiological roles, including pigmentation, steroid secretion, energy homeostasis, and food intake. Five G-protein-coupled receptors (MC1R-MC5R) make up the melanocortin receptor (MCR) family. The MC1R regulates pigmentation, the MC2R is an essential part of the hypothalamic-pituitary-adrenal axis, the MC3R, MC4R, and MC5R are involved in exocrine function, and they all play a significant role in energy homeostasis.
A number of neuropeptides known as melanocortins, such as adrenocorticotropic hormone (ACTH) and,, and -melanocyte-stimulating hormones (MSHs), activate MCRs. Pro-opiomelanocortin, a common polypeptide precursor that is primarily expressed in the hypothalamus and pituitary, is processed post-translationally to produce melanocortins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V78684 | CCZ01048 TFA | CCZ01048 TFA is an α-MSH analogue with high binding affinity to the melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. | |
|
V70585 | Chlorophorin | 537-41-7 | Chlorophorin is an inhibitor (blocker/antagonist) of the Melanocortin Receptor. |
|
V79400 | Fenoprofen-13C6 sodium hydrate (Fenoprofen 13C6) | Fenoprofen-13C6 (sodium hydrate) is 13C (carbon 13) labelled Fenoprofen. | |
|
V76917 | HS014 TFA | HS014 TFA is a potent and specific melanocortin-4 (MC4) receptor antagonist (inhibitor) with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. | |
|
V76916 | HS024 TFA | HS024 is a selective MC4 receptor antagonist (inhibitor) with Ki of 0.29, 3.29, 5.45 and 18.6 nM for MC4, MC5, MC3 and MC1 respectively. | |
|
V70577 | IIIM-8 | 1128053-62-2 | IIIM-8 is a melanin production inhibitor. |
|
V70581 | JKC363 | 436083-30-6 | JKC363 is a selective melanocortin MC4 receptor antagonist, with an affinity 90 times higher at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). |
|
V80448 | JKC363 TFA | JKC363 TFA is a selective melanocortin MC4 receptor antagonist, with 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). | |
|
V4507 | JNJ-10229570 | 524923-88-4 | JNJ-10229570 is a novel, potent and selective antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R) with the potential to treat primary human sebaceous cells and for the treatment of acne and other sebaceous gland pathologies. |
|
V70574 | Lys-γ3-MSH(human) | 156159-18-1 | Lys-γ3-MSH (human) is a melanocortin peptide extracted from the C-terminus of the POMC fragment. |
|
V80654 | Lys-γ3-MSH(human) TFA | Lys-γ3-MSH (human) TFA is a melanocortin peptide extracted from the C-terminus of the POMC fragment. | |
|
V70583 | MCL0020 | 475498-26-1 | MCL0020 is a potent and specific melanocortin MC4 receptor antagonist (inhibitor) with IC50 of 11.63 nM. |
|
V29413 | Melanotan I (Afamelanotide; CUV1647) | 75921-69-6 | Afamelanotide (Melanotan I; MT-I; CUV-1647; MBJ05; trade name Scenesse) is a synthetic peptide analog of α-melanocyte stimulating hormone (α-MSH), acting as a melanocortin receptor agonist and has been approved for use to prevent skin damage from the sun in people with erythropoietic protoporphyria in EU and USA. |
|
V70568 | ML-00253764 hydrochloride | 1706524-94-8 | ML-00253764 is a non-peptide melanocortin receptor 4 (MC4R) antagonist (inhibitor) with Ki and IC50s of 0.16 µM and 0.103 µM, respectively. |
|
V70564 | ML00253764 | 681847-92-7 | ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist that can cause apoptosis by inhibiting ERK1/2 and Akt phosphorylation and has anti-neoplastic activity. |
|
V70566 | MSG606 | 1416983-77-1 | MSG606 is a selective MC1R (melanocortin 1 receptor) antagonist that may be utilized to study neuro-protective (neuro-protection) effects. |
|
V80844 | MSG606 TFA | MSG606 TFA is a potent human MC1 receptor antagonist (IC50=17 nM). | |
|
V70569 | N,N′-Diferuloylputrescine | 42369-86-8 | N,N′-Diferuloylputrescine is an inhibitor (blocker/antagonist) of pigmentation and reduced pigmentation by 57%. |
|
V76692 | Nonapeptide-1 acetate salt (Melanostatine-5 acetate salt) | Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). | |
|
V51034 | PF-07258669 | 2755890-53-8 | PF-07258669 is a melanocortin 4 receptor (MC4) antagonist. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
