[D-Arg6,Pro9-NEt]Salmon gonadotropin-releasing hormone

Alias: [D-Arg6,Pro9-NEt]Salmon gonadotropin-releasing hormone
Cat No.:V40902 Purity: ≥98%
sGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analog.
[D-Arg6,Pro9-NEt]Salmon gonadotropin-releasing hormone Chemical Structure CAS No.: 96497-82-4
Product category: GnRH Receptor
This product is for research use only, not for human use. We do not sell to patients.
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Product Description
sGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analog. sGnRH-A can stimulate growth hormone secretion and can also be used as an ovulation inducer for artificial insemination.
Biological Activity I Assay Protocols (From Reference)
ln Vitro
sGnRH-A (0.1 nM-1 μM, 24 h) lethally increases GH mRNA levels and stimulates GH death [1]. sGnRH-A (10 nM, 6 h) induces an increase in growth hormone levels that is nearly 5 times higher than death [1].
References
[1]. Wen-Sheng Li, et al. Effects of gonadotropin-releasing hormone on growth hormone secretion and gene expression in common carp pituitary. Comp Biochem Physiol B Biochem Mol Biol. 2002 Jun;132(2):335-41.
[2]. Bamidele, O, et al. Salmon gonadotropin-releasing hormone analogue (sGnRHa) as a potent ovulation inducer for artificial insemination in rabbit. Veterinary Sciences: Research and Reviews, 5(2): 66-72.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C64H83N17O12
Molecular Weight
1282.45052
Exact Mass
1281.64
CAS #
96497-82-4
SMILES
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
InChi Key
PYXUQVSYYFRRBD-OIAWHVPDSA-N
InChi Code
InChI=1S/C64H83N17O12/c1-4-68-62(92)53-16-10-24-81(53)63(93)51(25-35(2)3)79-58(88)48(27-37-30-70-43-13-7-5-11-41(37)43)76-55(85)45(15-9-23-69-64(65)66)74-57(87)47(26-36-17-19-40(83)20-18-36)75-61(91)52(33-82)80-59(89)49(28-38-31-71-44-14-8-6-12-42(38)44)77-60(90)50(29-39-32-67-34-72-39)78-56(86)46-21-22-54(84)73-46/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,87)(H,75,91)(H,76,85)(H,77,90)(H,78,86)(H,79,88)(H,80,89)(H4,65,66,69)/t45-,46+,47+,48+,49+,50+,51+,52+,53+/m1/s1
Chemical Name
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Synonyms
[D-Arg6,Pro9-NEt]Salmon gonadotropin-releasing hormone
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 0.7798 mL 3.8988 mL 7.7976 mL
5 mM 0.1560 mL 0.7798 mL 1.5595 mL
10 mM 0.0780 mL 0.3899 mL 0.7798 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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