In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V101737 | (+)-Butaclamol hydrochloride | 55528-07-9 | (+)-Butalamol hydrochloride is a neuroleptic with dopamine receptor blocking activity. |
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V84344 | (+)-UH 232 (UH 232) | 95999-12-5 | (+)-UH 232 is a partially selective agonist of D3 receptors with an intrinsic activity of 0.2-0.4. |
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V114774 | (-)-IHCH7041 | 2813335-07-6 | (-)-IHCH7041 (compound (-)-(S)-I-10) is a selective, orally effective dopamine D2 receptor agonist with a Ki value of 22.44 nM. |
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V112528 | (-)-MDO-NPA | 81264-57-5 | (-)-MDO-NPA is an N-propylnormorphine analogue and a D1R/D2R dual-target ligand. |
|
V19599 | (-)-Quinpirole HCl | 85798-08-9 | Quinpirole HCl [(-)-LY 171555] is a highly potent psychoactive drug and research chemical which acts as a high affinity and selective D₂ and D₃ receptor agonist. |
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V71727 | (R)-Preclamol ((+)-3-PPP) | 85976-54-1 | (R)-Preclamol is a dopamine (DA) agonist/activator with autoreceptor and postsynaptic receptor stimulating properties. |
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V71759 | (R)-Preclamol hydrochloride ((+)-3-PPP hydrochloride) | 89874-80-6 | (R)-Preclamol HCl ((+)-3-PPP HCl) is the R-enantiomer of Preclamol HCl. |
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V113151 | (R)-SCH-23982 hydrochloride | 300561-61-9 | (R)-SCH-23982 hydrochloride is the R optical isomer of SCH-23982 hydrochloride. |
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V101190 | (R)-SKF-81297 hydrobromide | 253446-15-0 | (R)-SKF-81297 hydrobromide is the R isomer of SKF-81297. |
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V71721 | (Rac)-PF-06256142 | 1609580-97-3 | (Rac)-PF-06256142 is the weaker enantiomer of PF-06256142. |
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V71728 | (Rac)-Razpipadon (PW0464) | 1643462-93-4 | PW0464 is a full G protein ligand with nanomolar activity and an agonist of D1R with EC50 of 5.8 nM (Gs-cAMP). |
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V71221 | (Rac)-Rotigotine (N-0437) | 92206-54-7 | (Rac)-Rotigotine (N-0437) is the racemate of Rotigotine. |
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V71718 | (Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751) | 1643462-64-9 | (Rac)-Tavapadon ((Rac)-PF-06649751) is a specific, non-catecholic dopamine D1 receptor agonist. |
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V115772 | (S)-SCH-23390 hydrochloride | 1217443-99-6 | (S)-SCH-23390 hydrochloride is the S-enantiomer of SCH-23390. |
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V117172 | (Z)-Flupenthixol decanoate | 69079-98-7 | (Z)-Fluoperthixene decanoate is the cis isomer of fluoperthixene decanoate. |
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V112104 | (±)-N-Propylnorapomorphine | 57559-68-9 | (±)-N-propylnoraporphine (page 40; propylnoraporphine) is a dopamine D2 receptor agonist. |
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V116230 | 1192U90 | 155289-31-9 | 1192U90 is an antipsychotic compound that is a dopamine D2 receptor antagonist and a serotonin 5-HT1a receptor agonist. |
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V110315 | 5-OH-DPAT | 68593-96-4 | 5-OH-DPAT (5-hydroxy-DPAT) is a potent and selective dopamine D2 receptor agonist with no effect on 5-HT receptors. |
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V115390 | 7-Hydroxy-DPAT | 74938-11-7 | 7-Hydroxy-DPAT (7-OH-DPAT) is a selective D3 dopamine receptor agonist. |
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V101474 | 7-Hydroxy-PIPAT | 159559-71-4 | 7-Hydroxy-PIPAT (Compound 2) is a D3R agonist. |
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