Calcitonin-receptor-like receptor (CRLR), a type II (family B) G-protein-coupled receptor, and receptor-activity-modifying protein 1 (RAMP1), a single-membrane-pass protein, combine to form the CGRP receptor. Both CGRP binding and CLR cell-surface expression require RAMP1. A GPCR from family B is the CLR.
The trigeminal system produces large amounts of the neuropeptide CGRP, which is also widely expressed in the peripheral and central nervous systems. Vasodilation, the perception of painful stimuli, and inflammation are just a few of the roles that CGRP plays. Through interactions with its receptors, CGRP brings about biological effects. The CGRP-A and CGRP-B subtypes of CGRP receptors exist.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V77286 | Adrenomedullin (1-50), rat | Adrenomedullin (1-50), rat is a 50-amino-acid polypeptide that induces arterial vasodilation by activating the CGRP1 receptor. | |
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V77824 | Adrenomedullin (16-31), human TFA | Adrenomedullin (16-31), human TFA is the 16-31 amino acid (AA) fragment of human adrenomedullin (hADM). | |
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V71610 | Adrenotensin (human) (Pro-ADM-153-185 (human)) | 166546-72-1 | Adrenotensin (human) (Pro-ADM-153-185 (human)) is the 153-185 fragment of the adrenotensin (Adrenotensin) precursor peptide. |
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V114582 | Adrenotensin (human) TFA | Human adrenaline (Pro-ADM-153-185 (human)) TFA is the 153-185 fragment of the adrenaline precursor peptide. | |
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V116154 | BMS-846372 | 1190363-03-1 | BMS-846372 (compound 5) is an orally effective CGRP antagonist (Ki = 0.07 nM). |
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V77174 | Cagrilintide acetate | Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylating amylase analog. | |
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V86578 | Calcitonin (salmon) (acetate) | 158000-61-4 | Calcitonin (salmon) (acetate) is the acetate form of calcitonin salmon. |
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V77172 | Calcitonin Gene Related Peptide (CGRP) II, rat TFA | Calcitonin Gene Related Peptide (CGRP) II, rat TFA, an activator of CGRP receptors, is a potent and long-lasting vasodilator. | |
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V106116 | Calcitonin-13C6,15N4 (salmon) TFA | Calcitonin-13C6,15N4 (Salmon) (Salmon Calcitonin-13C6,15N4) TFA is 13C and 15N labeled calcitonin (Salmon). | |
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V96718 | CGRP antagonist 6 | CGRP antagonist 6 (Compound 23) is a CGRP receptor antagonist (Ki: 0.84 nM). | |
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V51239 | Chrysin 6-C-glucoside 8-C-arabinoside | 185145-34-0 | Chrysin 6-C-glucoside 8-C-arabinoside inhibits the release of CGRP and the activation of TRPV1 channels. |
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V102473 | CRSP-1 | 697327-12-1 | CRSP-1 is calcitonin receptor stimulating peptide-1. |
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V114445 | CTR/AMYR modulator-1 | 3097482-67-9 | CTR/AMYR modulator-1 (compound 103) is a calcitonin/amyrin receptor modulator. |
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V109058 | Desfluoro-BMS-694153 | 773886-89-8 | Desfluoro-BMS-694153 (compound 3) is a calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki value of 0.01 nM. |
|
V3059 | GRA Ex-25 | 307983-31-9 | GRA Ex-25 is a novel and potent inhibitor of glucagon receptor with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively. |
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V71608 | HTL22562 | 2097085-63-5 | HTL22562 is a calcitonin gene-related peptide (CGRP) receptor blocker (antagonist) indicated for acute investigation in migraine. |
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V4317 | MK-3207 | 957118-49-9 | MK-3207 is a novel, potent and orally bioactive CGRP (Calcitonin gene related peptide) receptor antagonist with IC50 and Ki of 0.12 nM and 0.022 nM, it is highly selective versus human AM1, AM2, CTR, and AMY3. |
|
V1495 | MK-3207 HCl | 957116-20-0 | MK-3207 HCl (MK-3207; MK3207), the hydrochloride salt of MK3207, is a novel, potent and orally bioactive CGRP (Calcitonin gene related peptide) receptor antagonist with important biological activity. |
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V111240 | PCC0105005 | 2921670-99-5 | PCC0105005 is a dual-target CGRP receptor antagonist (IC50 = 1.01 nM) and a 5-HT1F receptor partial agonist (EC50 = 77.91 nM). |
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V4067 | Rimegepant (BMS927711) | 1289023-67-1 | Rimegepant (formerly known as BMS-927711; Nurtec ODT) is a highly potent, selective, orally bioavailable, cometitive calcitonin gene-related peptide (CGRP) receptor antagonist with aKivalue of 0.027 nM. |
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