The three G-protein-coupled cannabinoid receptor subtypes currently recognized are central (CB1), peripheral (CB2), and GPR55. The majority of CB1 receptors are found at central and peripheral nerve terminals. CB2 receptors are mainly found in immune cells and non-neuronal tissues where they regulate cytokine release and cell migration. According to recent reports, the CNS may also express CB2 receptors. Non-CB1/CB2 receptors known as GPR55 show affinity for endogenous, botanical, and synthetic cannabinoids. Anandamide and 2-arachidonylglycerol are examples of endogenous ligands for cannabinoid receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71574 | GAT564 | 2851895-01-5 | GAT564 (Compound 15d) is a potent allosteric modulator of the cannabinoid 1 receptor (CB1R) with EC50s of 87 and 320 nM for cAMP and β-arrestin2, respectively. |
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V71607 | GW 833972A | 1092502-33-4 | GW 833972A is a selective CB2 receptor agonist. |
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V1519 | GW842166X | 666260-75-9 | GW842166X (GW-842166X; GW842166; GW 842166X) is a novel, potent and highly selective agonist of cannabinoid receptor CB2 receptor with potential anti-inflammatory activity. |
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V71556 | Hemopressin (human, mouse) | 1314035-51-2 | Hemopressin is a nonapeptide extracted from the hemoglobin α1 chain and was originally extracted from rat brain homogenate. |
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V71571 | Hemopressin(human, mouse) TFA | 1431329-48-4 | Hemopressin TFA is a nonapeptide extracted from the hemoglobin α1 chain and was originally extracted from rat brain homogenate. |
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V71566 | Hemopressin(rat) | 568588-77-2 | Hemopressin(rat) is a nonapeptide extracted from the hemoglobin α1 chain and was originally extracted from rat brain homogenate. |
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V71563 | Hemopressin(rat) TFA | 1431329-47-3 | Hemopressin(rat) TFA is a nonapeptide extracted from the hemoglobin α1 chain and was originally extracted from rat brain homogenate. |
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V71598 | Ibipinabant (SLV319; BMS-646256) | 464213-10-3 | Ibipinabant (SLV319) is a specific and orally bioactive cannabinoid CB1 receptor antagonist (inhibitor) with a Ki of 7.8 nM. |
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V22612 | Iodopravadoline (AM630) | 164178-33-0 | Iodopravadoline, formerly known as AM630, is an inverse agonist at the human cannabinoid CB1 receptor. |
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V3002 | JD5037 | 1392116-14-1 | JD5037 is a novel and potent inverse agonist of peripherally restricted (PR) cannabinoid 1 (CB1) receptors with Ki of 0.35 nM. |
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V71580 | LEI-101 | 2250025-91-1 | LEI-101 is a specific, orally bioactive cannabinoid CB2 receptor agonist/activator with pEC50 of 8 for hCB2 and pKi of less than 4 for hERG. |
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V5025 | Linoleylethanolamide | 68171-52-8 | Linoleylethanolamide is a novel and potent endocannabinoid agent that acts by binding to TRPV1 (Ki = 5.60 uM), increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner. |
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V3840 | LY2828360 | 1231220-79-3 | LY2828360 (LY-2828360) is a potent, slowly signaling, G protein-biased CB2 cannabinoid agonist that lacked both toxicity and efficacy in a clinical trial for osteoarthritis. |
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V71553 | Monlunabant ((S)-MRI-1891) | 2712480-46-9 | Monlunabant ((S)-MRI-1891) is a solid dispersion compound and a cannabinoid CB1 receptor blocker/inhibitor. |
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V49231 | N-Arachidonyldopamine | 199875-69-9 | N-Arachidonyldopamine is a potent and specific endogenous CB1 receptor agonist (activator) with Ki of 250 nM. |
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V71586 | Noladin ether | 222723-55-9 | Noladin ether is a specific cannabinoid CB1 receptor agonist/activator with a Ki of 21.2 nM. |
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V71596 | O-2050 | 1883545-42-3 | O-2050 is a high-affinity cannabinoid CB1 receptor antagonist (inhibitor) with a Ki of 2.5 nM. |
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V71569 | O-2093 | 439080-01-0 | O-2093 is a selective endocannabinoid anandamide (AEA) reuptake inhibitor (antagonist) with IC50 of 17.3 μM. |
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V71572 | O-7460 | 1572051-31-0 | O-7460 is a potent and specific inhibitor of DAGLα with IC50 of 0.69 μM. |
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V71554 | O1918 | 536697-79-7 | O1918 is a selective antagonist of non-CB1 receptors and GPR18. |
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