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Adenylate Cyclase

Adenylate Cyclase

Adenosine triphosphate (ATP) is converted into cyclic adenosine monophosphate (cAMP) by enzymes called adenylyl cyclases (ACs). Adenylyl cyclases combine extracellular stimuli with positive and negative signals that act through G protein-coupled cell-surface receptors in order to finely control cAMP levels inside of cells. Nine membrane-bound AC isoforms and one soluble AC are expressed in humans.

Transmembrane ACs are divided into four groups based on their regulatory characteristics: Group I contains the Ca2+/calmodulin-stimulated AC1, AC3, AC8, Group II contains the G-stimulated but Ca2+-insensitive AC2, AC4, AC7, Group III contains the Gi/Ca2+/PKA-inhibited AC5, AC6, and Group IV contains the forskolin/Ca2+/G-insensitive AC9. Forskolin, a diterpene obtained from the root of the plant Coleus forskohlii, which directly activates all isoforms of transmembrane ACs except AC9, has no effect on the soluble AC, unlike the transmembrane ACs.

Adenylate Cyclase related products

Structure Cat No. Product Name CAS No. Product Description
2-Chloro-ADP V103008 2-Chloro-ADP 16506-88-0 2-Chloro-ADP (2-chloroadenosine 5'-diphosphate) is an adenosine 5'-diphosphate (ADP) derivative that induces platelet aggregation and inhibits stimulated adenylate cyclase.
2-Chloro-ADP sodium V103009 2-Chloro-ADP sodium 82927-78-4 2-Chloro-ADP (2-chloroadenosine 5'-diphosphate) sodium is an adenosine 5'-diphosphate (ADP) derivative that induces platelet aggregation and inhibits stimulated adenylate cyclase.
AC10142A V93220 AC10142A 2963581-29-3 AC10142A is a selective adenylate cyclase type 1 inhibitor with IC50 of 0.26 μM.
AC2 selective-IN-1 V85124 AC2 selective-IN-1
Adenylyl cyclase-IN-1 V74623 Adenylyl cyclase-IN-1 731827-16-0 Adenylyl cyclase-IN-1 is an inhibitor (blocker/antagonist) of adenylyl cyclase and may be used to be utilized in the research of ocular hypotonia.
Albanin A (Albanin A) V71481 Albanin A (Albanin A) 73343-42-7 Albanin A is a flavonoid that can inhibit glutamate release and exerts neuro-protection effects in vivo by reducing Ca2+/calmodulin/adenylate cyclase 1 (AC1) activation in synaptosomes.
GA 0113 V93180 GA 0113 200639-61-8 GA 0113 is a potent, oral angiotensin II (Ang II) AT1 receptor antagonist.
Glycerophosphoinositol 4-phosphate V111347 Glycerophosphoinositol 4-phosphate 129830-96-2 Glycerol phosphoinositol 4-phosphate (GroPIns-4-P) is a metabolite of phospholipase A and an inhibitor of adenylate cyclase.
KH7 V23223 KH7 330676-02-3 KH7 (KH-7) is a novel and potent Inhibitor of Sac (soluble adenylyl cyclase) with IC50s of 3-10 μM against both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays.
KR-31080 V93068 KR-31080 174800-22-7 KR-31080 is an imidazo[4,5-b]pyridine derivative.
L 858051 dihydrochloride V118635 L 858051 dihydrochloride 115116-37-5 858051 dihydrochloride is a Forskolin analog that can activate adenylate cyclase and regulate intracellular cAMP levels, especially enhancing CNG currents in cardiomyocytes.
Lysipressin acetate (Lysine vasopressin acetate; [Lys8]-Vasopressin acetate) V74621 Lysipressin acetate (Lysine vasopressin acetate; [Lys8]-Vasopressin acetate) 83968-49-4 Lysipressin (Lysine vasopressin) acetate is an antidiuretic hormone discovered in pigs.
mAC2-IN-1 V80661 mAC2-IN-1 mAC2-IN-1 (compound 14) is a potent and specific inhibitor of human adenylyl cyclase (mAC) with IC50 of 4.45 μM.
MANT-cGMP V111570 MANT-cGMP 83707-15-7 MANT-cGMP is a ribose-substituted nucleotide that is an inhibitor of adenylate cyclase (AC) with a Ki value of 100 μM and a pKi value of 4.
MANT-GppNHp V109179 MANT-GppNHp 148821-01-6 MANT-GppNHp is a competitive adenylate cyclase (AC) inhibitor and belongs to the class of fluorescently labeled GTP analogs.
Mant-GTPγS V74624 Mant-GTPγS 136749-24-1 Mant-GTPγS is a GTP mimetic and a potent competitive adenylyl cyclase (AC) inhibitor.
Mant-GTPγS triammonium V80678 Mant-GTPγS triammonium Mant-GTPγS triammonium is a GTP mimetic and a potent competitive adenylyl cyclase (AC) inhibitor.
Saprisartan potassium V96886 Saprisartan potassium 146613-90-3 Saprosartan (GR 138950) potassium is a selective, long-acting AT1 receptor antagonist.
SQ-22536 (NSC-53339) V2586 SQ22536 (NSC-53339) 17318-31-9 SQ22536 (formerly NSC-53339) is a novel and effective inhibitor of adenylyl cyclase(AC) with an IC50 of 1.4 μM.
TDI-10229 V74619 TDI-10229 2810887-45-5 TDI-10229 is an orally bioactive soluble adenylyl cyclase (sAC, ADCY10) inhibitor (IC50 195 nM).
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