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5-HT Receptor

5-HT Receptor

5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.

5-HT Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Norcisapride V87765 (+)-Norcisapride 202590-69-0 (+)-Norcisapride (Ticalopride) is a potent 5-HT4 agonist and 5-HT3 antagonist.
(+)-Norfenfluramine ((S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine) V71145 (+)-Norfenfluramine ((S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine) 19036-73-8 (+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is a selective 5-HT2B receptor agonist (Ki: 11.2 nM).
(+)-Norfenfluramine hydrochloride V71147 (+)-Norfenfluramine hydrochloride 37936-89-3 (+)-Norfenfluramine HCl is the major hepatic metabolite of (+)-fenfluramine and is a selective 5-HT2B receptor agonist (Ki: 11.2 nM).
(+)-OSU6162 V84727 (+)-OSU6162 160777-43-5
(-)-5-HT2C agonist-3 V96924 (-)-5-HT2C agonist-3 2104810-16-2 (-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, EC50 values for 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM.
(-)-Eseroline fumarate (Eseroline fumarate) V71190 (-)-Eseroline fumarate (Eseroline fumarate) 70310-73-5 (-)-Eseroline fumarate is a metabolite of the AChE inhibitor Physostigmine.
(R)-Indeloxazine benzenesulfonate V89038 (R)-Indeloxazine benzenesulfonate 1623762-83-3 (R)-Indeloxazine benzenesulfonate (AS1069562) is an orally active 5-HT and NE reuptake inhibitor with IC50 values of 0.35 μM and 3.3 μM, respectively.
（R，R）-盐酸帕洛司琼 V3896 (R,R)-Palonosetron Hydrochloride 135729-75-8 (R,R)-Palonosetron Hydrochloride isthe active R,R-enantiomer of Palonosetron HCl (RS25259, RS-25259 197; trade name: Aloxi and Akynzeo) which is a 5-HT3 antagonist approved in 2018 in the prevention and treatment of chemotherapy-induced nausea and vomiting.
(Rac)-WAY-161503 hydrochloride V71157 (Rac)-WAY-161503 hydrochloride 276695-22-8 (Rac)-WAY-161503 HCl is a specific, high-affinity 5-HT2C receptor agonist/activator with a Ki of 4 nM and EC50 of 12 nM.
(S)-Bexicaserin V71196 (S)-Bexicaserin 2035818-21-2 (S)-Bexicaserin (Compound 2) is a 5-HT2C receptor agonist (activator) with potential for studying obesity and psychiatric-related diseases.
(S)-PF-04995274 V104813 (S)-PF-04995274 2170558-28-6 (S)-PF-04995274 is a 5-hydroxytryptamine receptor 4 (5-HT4R) partial agonist and an isomer of PF-04995274.
(S)-Renzapride ((S)-BRL 24924) V77357 (S)-Renzapride ((S)-BRL 24924) (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride.
(±)-Fabesetron V97004 (±)-Fabesetron 129299-72-5 (±)-Fabesetron ((±)-FK1052 free base) is the racemic form of Fabesetron.
(±)-LY-426965 dihydrochloride V102693 (±)-LY-426965 dihydrochloride 228418-81-3 (±)-LY-426965 dihydrochloride is the racemate of LY-426965.
1,1,1-Trifluoro-10(Z)-nonadecen-2-one V102820 1,1,1-Trifluoro-10(Z)-nonadecen-2-one 177987-23-4 1,1,1-Trifluoro-10(Z)-nonadecen-2-one (Compound 1) is an inhibitor of oleamide hydrolase.
1-(1-Naphthyl)piperazine hydrochloride V102566 1-(1-Naphthyl)piperazine hydrochloride 104113-71-5 1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-naphthylpiperazine hydrochloride) is a serotonin derivative of Quipazine.
1-(2-Methoxyphenyl)piperazine hydrochloride V106530 1-(2-Methoxyphenyl)piperazine hydrochloride 5464-78-8 1-(2-Methoxyphenyl)piperazine hydrochloride is a key intermediate of antipsychotic drugs. It has a high affinity for 5-hydroxytryptamine receptors and 5-HT and can be used to synthesize intestinal anthelmintics such as piperazine phosphate and piperazine citrate, as well as fluphenazine hydrochloride and rifampicin.
1-(Carboxymethyl)cyclohexanecarboxylic acid V94152 1-(Carboxymethyl)cyclohexanecarboxylic acid 67950-95-2 1-(Carboxymethyl)cyclohexanecarboxylic acid (1-carboxycyclohexaneacetic acid; gabapentin impurity E) is a potential impurity in commercial formulations of the antiepileptic drug gabapentin.
2,4-DMA hydrochloride V103221 2,4-DMA hydrochloride 33189-36-5 2,4-DMA hydrochloride is an amphetamine and serotonin 5-HT2 receptor agonist with an apparent PA2 value of 5.6.
2,6-DMA hydrochloride V107450 2,6-DMA hydrochloride 3904-11-8 2,6-DMA hydrochloride is an amphetamine and serotonin 5-HT2 receptor agonist with a pA2 value of 5.09.
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