5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V87765 | (+)-Norcisapride | 202590-69-0 | (+)-Norcisapride (Ticalopride) is a potent 5-HT4 agonist and 5-HT3 antagonist. |
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V71145 | (+)-Norfenfluramine ((S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine) | 19036-73-8 | (+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). |
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V71147 | (+)-Norfenfluramine hydrochloride | 37936-89-3 | (+)-Norfenfluramine HCl is the major hepatic metabolite of (+)-fenfluramine and is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). |
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V84727 | (+)-OSU6162 | 160777-43-5 | |
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V96924 | (-)-5-HT2C agonist-3 | 2104810-16-2 | (-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, EC50 values for 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM. |
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V71190 | (-)-Eseroline fumarate (Eseroline fumarate) | 70310-73-5 | (-)-Eseroline fumarate is a metabolite of the AChE inhibitor Physostigmine. |
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V113218 | (R)-DOI hydrochloride | 82864-02-6 | (R)-DOI hydrochloride is a selective 5-HT2A receptor agonist. |
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V89038 | (R)-Indeloxazine benzenesulfonate | 1623762-83-3 | (R)-Indeloxazine benzenesulfonate (AS1069562) is an orally active 5-HT and NE reuptake inhibitor with IC50 values of 0.35 μM and 3.3 μM, respectively. |
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V114741 | (R)-LY-41 | 136296-43-0 | (R)-LY-41 is the R-enantiomer of LY-41, which is a derivative of 2-S-aminotetrahydronaphthalene and an analog of 8-OH-DPAT. |
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V3896 | (R,R)-Palonosetron Hydrochloride | 135729-75-8 | (R,R)-Palonosetron Hydrochloride isthe active R,R-enantiomer of Palonosetron HCl (RS25259, RS-25259 197; trade name: Aloxi and Akynzeo) which is a 5-HT3 antagonist approved in 2018 in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
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V71157 | (Rac)-WAY-161503 hydrochloride | 276695-22-8 | (Rac)-WAY-161503 HCl is a specific, high-affinity 5-HT2C receptor agonist/activator with a Ki of 4 nM and EC50 of 12 nM. |
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V115909 | (S)-5-HT2CR agonist 1 | 2841458-00-0 | (S)-5-HT2CR agonist 1 (compound (S)-16k) is a selective 5-HT2CR receptor agonist with an EC50 of 14 nM. |
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V71196 | (S)-Bexicaserin | 2035818-21-2 | (S)-Bexicaserin (Compound 2) is a 5-HT2C receptor agonist (activator) with potential for studying obesity and psychiatric-related diseases. |
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V114524 | (S)-LY-41 | 136296-40-7 | (S)-LY-41 is the R-enantiomer of LY-41, which is a derivative of 2-S-aminotetrahydronaphthalene and an analog of 8-OH-DPAT. |
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V104813 | (S)-PF-04995274 | 2170558-28-6 | (S)-PF-04995274 is a 5-hydroxytryptamine receptor 4 (5-HT4R) partial agonist and an isomer of PF-04995274. |
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V77357 | (S)-Renzapride ((S)-BRL 24924) | (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride. | |
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V97004 | (±)-Fabesetron | 129299-72-5 | (±)-Fabesetron ((±)-FK1052 free base) is the racemic form of Fabesetron. |
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V102693 | (±)-LY-426965 dihydrochloride | 228418-81-3 | (±)-LY-426965 dihydrochloride is the racemate of LY-426965. |
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V102820 | 1,1,1-Trifluoro-10(Z)-nonadecen-2-one | 177987-23-4 | 1,1,1-Trifluoro-10(Z)-nonadecen-2-one (Compound 1) is an inhibitor of oleamide hydrolase. |
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V111217 | 1-(1-Naphthyl)piperazine | 57536-86-4 | 1-(1-Naphthyl)piperazine is a 5-HT receptor modulator, acting as both a 5-HT2A receptor antagonist and a 5-HT1A receptor agonist, with a binding constant Ki of 120 nM to the human 5-HT6 receptor. |
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