The class of proteins known as Sirtuin (Sir2 proteins) includes enzymes with deacylase, deacetylase, desuccinylase, demalonylase, demyristoylase, and depalmitoylase activity. Sirtuins control crucial biological processes in eukaryotes, archaea, and bacteria. Sirtuins have been linked to a variety of cellular functions, including energy efficiency and alertness under low-calorie conditions as well as aging, transcription, apoptosis, inflammation, and stress resistance. Circadian clocks and mitochondrial biogenesis can both be regulated by sirtuins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V51326 | Nicotinamide riboside tartrate | 2415657-86-0 | Nicotinamide riboside tartrate, an oral active NAD+ precursor, increases NAD+ levels and triggers SIRT1 and SIRT3 activation. |
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V3397 | PROTAC Sirt2 Degrader-1 | 2098487-75-1 | PROTAC Sirt2 Degrader-1 is a novel, potent PROTAC (proteolysis targeting chimera) which was identified based on the combination of the unique features of the sirtuin rearranging ligands (SirReals) as highly potent and isotype-selective Sirt2 inhibitors with thalidomide, a bona fide cereblon ligand. |
|
V55730 | Rencofilstat (CRV431) | 1383420-08-3 | Rencofilstat (CRV431) is a pan-cyclophilin inhibitor (antagonist) with IC50s of 2.5 nM, 3.1 nM, 2.8 nM and 7.3 nM for Cyp A, CypB, Cyp D and Cyp G respectively. |
|
V3246 | Salermide | 1105698-15-4 | Salermide is a potent inhibitor ofSirt1/2 (Sirtuin 1/2) with a strong cancer-specific proapoptotic effect mediated by Sirt1. |
|
V55738 | Selaginellin | 941269-84-7 | Selaginellin is an inhibitor (blocker/antagonist) of Reactive Oxygen Species and an activator of SIRT1. |
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V36310 | SIRT-IN-3 | 1211-19-4 | SIRT-IN-3 is a potent SIRT inhibitor (antagonist) with IC50 of 17 μM against SIRT1. |
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V55731 | SIRT1 activator 3 | 839699-72-8 | SIRT1 activator 3 is a potent activator of SIRT1 and inhibits TNF-α in a dose-dependent manner. |
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V36356 | SIRT1-IN-1 | 352554-02-0 | SIRT1-IN-1 is a selective SIRT1 inhibitor (antagonist) with IC50 of 0.205 μM. |
|
V79680 | Sirt1/2-IN-4 | Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC50 of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 2.0 μM (SIRT3). | |
|
V36348 | SIRT2-IN-10 | 296793-09-4 | SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor (antagonist) with IC50 of 1.3 μM. |
|
V36347 | SIRT2-IN-11 | 1005095-06-6 | SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor (antagonist) with IC50 of 18.5 μM. |
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V36346 | SIRT2-IN-9 | 522650-91-5 | SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with IC50 of 1.3 μM. |
|
V36339 | SIRT5 inhibitor 5 | 2883730-60-5 | SIRT5 inhibitor 5 is a potent SIRT5 inhibitor (antagonist) with IC50 of 0.21 µM. |
|
V55736 | SIRT5 inhibitor 6 | 2834736-82-0 | SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective inhibitor of SIRT5 with IC50 of 3.0 μM. |
|
V55737 | SIRT5 inhibitor 7 | 2951090-00-7 | SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor (antagonist) with anti-inflammatory activity. |
|
V53278 | Sirtuin modulator 3 | 708995-11-3 | Sirtuin modulator 3 (compound 129) is an N-phenylbenzamide analogue that works as a sirtuin modulator. |
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V36307 | Sirtuin modulator 4 | 327104-77-8 | Sirtuin modulator 4 (compound 12) is a sirtuin modulator. |
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V36276 | Sirtuin modulator 5 | 694469-31-3 | Sirtuin modulator 5 is a sirtuin modulator. |
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V55739 | Sirtuin-1 inhibitor 1 | 945114-10-3 | Sirtuin-1 inhibitor 1 (Compound 8) is an inhibitor (blocker/antagonist) of sirtuin-1 (Sirtuin-1). |
|
V35263 | SPC-180002 | 2170274-53-8 | SPC-180002 is a SIRT1/3 dual (bifunctional) inhibitor (antagonist) with IC50s of 1.13 μM and 5.41 μM respectively. |
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