RAD51-IN-1

Alias: RAD51-IN 1; RAD51-IN1; RAD51-IN-1
Cat No.:V2471 Purity: ≥98%
RAD51-IN-1 is an analogue of B02 and a potent inhibitor of RAD51.
RAD51-IN-1 Chemical Structure CAS No.: 2101739-18-6
Product category: RAD51
This product is for research use only, not for human use. We do not sell to patients.
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Product Description
RAD51-IN-1 is an analogue of B02 and a potent inhibitor of RAD51. RAD51-IN-1 could be used in cancer-related research.
Biological Activity I Assay Protocols (From Reference)
ln Vitro
RAD51 is an essential part of the DNA repair pathway for homologous recombination and is overexpressed in cancers that are resistant to drugs, such as aggressive triple-negative breast cancer (TNBC)[1].
RAD51-IN-1 (10 μM) reduces the ratio of RAD51 positive cells/cH2AX positive cells in MDA-MB-231 cell exposure to 6 Gy irradiation[1].
RAD51-IN-1 (10 μM) significantly reduces the formation of RAD51 foci induced by DNA damage when exposed to 6 Gy of radiation[1].
References

[1]. Quinazolinone derivatives as inhibitors of homologous recombinase RAD51. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C₂₂H₁₆CLN₃O
Molecular Weight
373.83
Exact Mass
373.1
Elemental Analysis
C, 70.68; H, 4.31; Cl, 9.48; N, 11.24; O, 4.28
CAS #
2101739-18-6
Appearance
Solid powder
SMILES
C1=CC=C2C(=C1)C(=O)N(C(=N2)/C=C/C3=CN=CC=C3)CC4=CC=C(C=C4)Cl
InChi Key
AQNDWTVLZSMOQU-FMIVXFBMSA-N
InChi Code
InChI=1S/C22H16ClN3O/c23-18-10-7-17(8-11-18)15-26-21(12-9-16-4-3-13-24-14-16)25-20-6-2-1-5-19(20)22(26)27/h1-14H,15H2/b12-9+
Chemical Name
3-[(4-chlorophenyl)methyl]-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one
Synonyms
RAD51-IN 1; RAD51-IN1; RAD51-IN-1
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: ~62.5 mg/mL (~167.2 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.6750 mL 13.3751 mL 26.7501 mL
5 mM 0.5350 mL 2.6750 mL 5.3500 mL
10 mM 0.2675 mL 1.3375 mL 2.6750 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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