ROCK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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ROCK

The AGC (PKA/PKG/PKC) family of serine-threonine kinases includes ROCK (Rho-associated protein kinase). Animals such as chicken, zebrafish, Xenopus, and mammals also have ROCKs (ROCK1 and ROCK2). With a molecular weight of 158 kDa, human ROCK1 is a significant RhoA small GTPase downstream effector. A kinase domain, an acoiled-coil region, and a Pleckstrin homology (PH) domain make up a mammalian ROCK. If RhoA-GTP is absent, the kinase activity of ROCKs is reduced by an autoinhibitory intramolecular fold. Since ROCK is a downstream effector protein of the small GTPase Rho, one of the primary regulators of the cytoskeleton, ROCK is involved in a variety of different cellular phenomena.

ROCK related products

Cat No.	Product Name	CAS No.	Product Description
V114421	(Rac)-NRL-1049 dihydrochloride	863638-93-1	(Rac)-BA 1049 is a racemic variant of NRL-1049 (BA-1049).
V118982	5-Nitro-1H-indazole-3-carbonitrile	90348-29-1	5-Nitro-1H-indazole-3-nitrile (DL0805) is a Rho kinase (ROCK) inhibitor with an IC50 value of 6.67 μM against ROCK-I.
V77245	AR-13324 analog mesylate	2095432-73-6	AR-13324 analog mesylate is an analog of AR-13324.
V32183	BDP5290	1817698-21-7	BDP5290 is a novel, potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.
V35094	CaMKP inhibitor sodium	52789-62-5	CaMKP inhibitor sodium is a selective ROCK1 inhibitor (antagonist) with IC50 of 14 nM.
V52297	CAY10746	2247240-76-0	CAY10746 is a selective Rho kinase (ROCK) inhibitor.
V131373	Centaureidin	17313-52-9	Centaureidin is an orally effective interferon agonist isolated from Bidens pilosa, with an EC50 value of 0.9 μg/mL.
V79028	Chroman 1 dihydrochloride		Chroman 1 di-HCl is a potent and specific ROCK inhibitor (antagonist) with stronger effect on ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM).
V88767	CMPD101 hydrochloride	1941168-71-3	CMPD101 hydrochloride, a membrane permeable, small molecule inhibitor of GRK2 and GRK3 with IC50 values of 18 nM and 5.4 nM, respectively.
V53061	Cotosudil	1258833-31-6	Cotosudil is a ROCK kinase inhibitor used in glaucoma or ocular hypertension research.
V115227	Desisopropyle-belumosudil	911417-89-5	Deisopropyl-beromosudil (compound 84) is a ROCK inhibitor (IC50 of 2.6 μM for ROCK 1 and 0.52 μM for ROCK 2).
V88763	DJ4	1681020-24-5	DJ4 is an ATP-competitive inhibitor of ROCK1/2 (IC50 values: 5 and 50 nM) and MRCKα/β (IC50 values: 10 and 100 nM).
V136770	Glycerophosphoinositol 4-phosphate disodium		Glycerophosphoinositol 4-phosphate disodium is a metabolite of phospholipase A and an inhibitor of adenylate cyclase.
V55052	Glycyl H-1152 hydrochloride	913844-45-8	Glycyl H-1152 HCl is a glycosyl analogue of the Rho-kinase inhibitor H-1152 di-HCl.
V2730	GSK180736A	817194-38-0	GSK180736A (GSK-180736A) is a GRK2 inhibitor thatwasdeveloped as a novel and potent Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitor whichbinds to GRK2 (G protein-coupled receptor kinase 2) with IC50of 0.77 μM; G protein-coupled receptors (GPCRs) are central to many physiological processes.
V2561	GSK269962 (GSK269962A)	850664-21-0	GSK269962 (also known as GSK269962A) is a novel, potent and selective inhibitor of ROCK (Rho-associated protein kinase) with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
V3320	GSK269962 HCl	2095432-71-4	GSK269962 HCl (also called GSK-269962A HCl),the hydrochloride salt ofGSK 269962A, is a selective ROCK (Rho-associated protein kinase) inhibitor with potential antihypertensive and cardioprotective activity.
V1345	GSK429286A	864082-47-3	GSK429286A (also known as RHO15;GSK 429286A;RHO-15;GSK-429286A)is a potent, orally bioactive, andselective inhibitor of ROCK1/2 with antihypertensive effects.
V67533	HA-100 dihydrochloride	210297-47-5	HA-100 di-HCl is a potent protein kinase inhibitor (antagonist) with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for PKG, PKA, PKC and MLC kinases respectively.
V52021	HA-100 hydrochloride	141543-63-7	HA-100 HCl is a potent protein kinase inhibitor (antagonist) with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for PKG, PKA, PKC and MLC kinases, respectively.