ROCK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

+MORE

ROCK

The AGC (PKA/PKG/PKC) family of serine-threonine kinases includes ROCK (Rho-associated protein kinase). Animals such as chicken, zebrafish, Xenopus, and mammals also have ROCKs (ROCK1 and ROCK2). With a molecular weight of 158 kDa, human ROCK1 is a significant RhoA small GTPase downstream effector. A kinase domain, an acoiled-coil region, and a Pleckstrin homology (PH) domain make up a mammalian ROCK. If RhoA-GTP is absent, the kinase activity of ROCKs is reduced by an autoinhibitory intramolecular fold. Since ROCK is a downstream effector protein of the small GTPase Rho, one of the primary regulators of the cytoskeleton, ROCK is involved in a variety of different cellular phenomena.

ROCK related products

Cat No.	Product Name	CAS No.	Product Description
V114421	(Rac)-NRL-1049 dihydrochloride	863638-93-1	(Rac)-BA 1049 is a racemic variant of NRL-1049 (BA-1049).
V118982	5-Nitro-1H-indazole-3-carbonitrile	90348-29-1	5-Nitro-1H-indazole-3-nitrile (DL0805) is a Rho kinase (ROCK) inhibitor with an IC50 value of 6.67 μM against ROCK-I.
V77245	AR-13324 analog mesylate	2095432-73-6	AR-13324 analog mesylate is an analog of AR-13324.
V32183	BDP5290	1817698-21-7	BDP5290 is a novel, potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.
V79028	Chroman 1 dihydrochloride		Chroman 1 di-HCl is a potent and specific ROCK inhibitor (antagonist) with stronger effect on ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM).
V88767	CMPD101 hydrochloride	1941168-71-3	CMPD101 hydrochloride, a membrane permeable, small molecule inhibitor of GRK2 and GRK3 with IC50 values of 18 nM and 5.4 nM, respectively.
V115227	Desisopropyle-belumosudil	911417-89-5	Deisopropyl-beromosudil (compound 84) is a ROCK inhibitor (IC50 of 2.6 μM for ROCK 1 and 0.52 μM for ROCK 2).
V88763	DJ4	1681020-24-5	DJ4 is an ATP-competitive inhibitor of ROCK1/2 (IC50 values: 5 and 50 nM) and MRCKα/β (IC50 values: 10 and 100 nM).
V24575	LX7101	1192189-69-7	LX7101 (LX-7101;LX 7101)is a novel, potent, pyrrolopyrimidine-based, and topically-usd inhibitor of LIM domain kinase 2 (LIMK2), which isa kinase associated with the regulation of intraocular pressure.
V88765	NRL-1049	1973494-16-4	NRL-1049 (BA-1049) is a ROCK2 selective inhibitor (IC50: 0.59 µM and 26 µM for ROCK2 and ROCK1, respectively). NRL-1049 reduces lysophosphatidic acid-induced ROCK activation in endothelial cells.
V111890	NRL-1049 dihydrochloride	1973494-17-5	NRL-1049 dihydrochloride (BA-1049) is a selective, orally effective inhibitor of Rho-associated protein kinase 2 (ROCK2) with an IC50 value of 0.59 μM.
V117082	NSC126188	31863-82-8	NSC126188 is a RhoB inducer.
V88762	Palmitoyl 3-carbacyclic phosphatidic acid	476310-22-2	Palmitoyl 3-carbacyclic phosphatidic acid is a palmitoylated Carba-type cyclic phosphatidic acid, an analog of lysophosphatidic acid (LPA).
V93210	PT109	2059104-90-2	PT109 is a multi-kinase inhibitor that plays an important role in anti-inflammation, anti-oxidation, neurogenesis, synapse formation, etc. by inhibiting JNK (JNK1: IC50=0.143μM; JNK2: IC50=0.831μM; JNK3: IC50=0.285μM) or other kinases (SGK1: IC50=1.34μM; SGK2: IC50=5.6μM; SGK3: IC50=26.4μM; ROCK2: IC50=34μM).
V13826	RKI-1313	1342276-76-9	RKI-1313 is a ROCK inhibitor (antagonist) with IC50s of 34 and 8 µM for ROCK 1 and ROCK 2 respectively.
V88764	ROCK-IN-10	1038549-25-5	ROCK-IN-10 (compound 50) is a potent ROCK inhibitor with IC50 values of 6 nM and 4 nM for ROCK1 and ROCK2, respectively.
V118285	ROCK2-IN-10		ROCK2-IN-10 is a highly effective and selective ROCK2 inhibitor (IC50 = 0.020 μM), with a ROCK2 selectivity that is 41 times greater than that of the ROCK1 subtype.
V118312	ROCK2-IN-11		ROCK2-IN-11 (compound A20) is a selective ROCK2 inhibitor with an IC50 of 0.18 μM for ROCK2, which is superior to its inhibitory efficacy against ROCK1.
V116709	ROCK2-IN-12	3086603-12-2	ROCK2-IN-12 (compound A25) is a selective ROCK2 inhibitor with an IC50 value of 7.0 nM for ROCK2 and even better inhibitory effect on ROCK1.
V79300	ROCK2-IN-5	3031515-48-4	ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic acid and ferulic acid.