Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V103968 | Mal-C5-Gly-Gly-Phe-MMAE | 3056230-14-6 | Mal-C5-Gly-Gly-Phe-MMAE (compound S5) is a drug-linker complex for ADC. |
|
V51814 | MAP4343 | 511-26-2 | MAP4343 is the 3-methyl ether analogue of Pregnenolone. |
|
V97934 | MASTL-IN-5 | 3024916-78-4 | MASTL-IN-5 (Compound 11) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with Ki value of 0.018 nM. |
|
V4654 | Mc-MMAE | 863971-24-8 | Mc-MMAE is a novel protective group for MMAE [(maleimidocaproyl)-conjugated monomethyl auristatin E], which is a highly potent mitotic/tubulininhibitor, and is a toxin payload/warhead in antibody drug conjugate (ADC). |
|
V75824 | Microtubule destabilizing agent-1 | 2850370-28-2 | Microtubule destabilizing agent-1 (Compound 12b) is a hydroxamic acid-based microtubule destabilizing agent (MDA). |
|
V101590 | Microtubule inhibitor 11 | Microtubule inhibitor 11 (compound 33) is a microtubule inhibitor with a mechanism of action similar to that of colchicine. | |
|
V85442 | Microtubule inhibitor 8 | 2310293-81-1 | |
|
V77772 | Microtubule stabilizing agent-1 | Microtubule stabilizing agent-1 (compound 3l) is a paclitaxel analogue that can effectively promote tubulin polymerization. | |
|
V5178 | MMAD | 203849-91-6 | MMAD (also known as Monomethyl auristatin D), anauristatin analog, is a novel and highly potent tubulin inhibitor/antimitotic agent that is often used as a warhead or a toxin payload in antibody drug conjugates (ADCs). |
|
V76759 | MMAD-d8 (Demethyldolastatin 10-d8; Monomethylauristatin D-d8; Monomethyl Dolastatin 10-d8) | MMAD-d8D is the deuterated form of MMAD. | |
|
V32943 | MMAF Hydrochloride | 1415246-68-2 | Monomethyl auristatin F (MMAF) HCl is a highly potent tubulin inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. |
|
V80793 | MMAF-d8 (Monomethylauristatin F D8) | D8-MMAF HCl is the deuterated form of MMAF HCl. | |
|
V76758 | MMAF-d8 hydrochloride | MMAF-d8 (HCl)e is the deuterium labelled form of MMAF HCl. | |
|
V51064 | MP-HJ-1b | MP-HJ-1b is a novel tubulin inhibitor. | |
|
V85264 | MY-1442 | ||
|
V26089 | Myoseverin | 267402-71-1 | Myoseverin is a reversible fission inducer of multinucleated myotubes into mononucleated fragments. |
|
V93697 | N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine | 1448364-29-1 | N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethylamine (Compound 14) is a tubulin polymerization inhibitor that can be used as an ADC payload. |
|
V88694 | Nab-Paclitaxel | Nab-Paclitaxel is an albumin-bound Paclitaxel nanoparticle preparation. | |
|
V41112 | Neuroinflammatory-IN-3 | 1202404-23-6 | Neuroinflammatory-IN-3 is a tubulin inhibitor and an anti-neuroinflammatory agent. |
|
V88400 | NH2-PEG3-VC-PAB-MMAE | 2641442-97-7 | NH2-PEG3-VC-PAB-MMAE is a drug-linker conjugate for ADC, which consists of a cleavable ADC linker (NH2-PEG3-VC-PAB) and a potent tubulin inhibitor Monomethyl auristatin E (MMAE). |
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