HSP

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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HSP

Heat shock proteins (HSPs) are a class of functionally related proteins that are involved in the folding and unfolding of other proteins. HSPs are a group of proteins that are produced in response to heat shock. When cells are subjected to high temperatures or other stresses, HSP expression rises. This increase in expression is controlled by transcription. Heat shock factor (HSF) is primarily responsible for the dramatic upregulation of the heat shock proteins, which is a crucial component of the heat shock response. Nearly every living thing, from bacteria to people, contains HSPs. Heat shock proteins seem to play a big part in the cardiovascular system. There have been reports of the roles of Hsp90, Hsp84, Hsp70, Hsp27, Hsp20, and alpha B crystallin in the cardiovasculature.

HSP related products

Cat No.	Product Name	CAS No.	Product Description
V67564	10,11-Dehydrocurvularin	21178-57-4	10,11-Dehydrocurvularin is a common mycotoxin and antibiotic.
V55770	17-DMAP-GA	169521-68-0	17-DMAP-GA, an analog of Geldanamycin, is an HSP90 inhibitor and can cause cell cycle abnormalities.
V106607	2-Methoxyhydroquinone	824-46-4	2-Methoxyhydroquinone is a phenolic compound that reduces TNF-α-induced chemokine (CC motif) ligand 2 (CCL2) production with an IC50 value of 64.3 µM.
V52504	3-Phenyltoxoflavin	32502-63-9	3-Phenyltoxoflavin is an analogue of Toxoflavin and an Hsp90 inhibitor.
V89622	[Au(TPP)]Cl	15695-27-9	[Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex and has anticancer activity.
V127961	A17 peptide	1140483-31-3	A17 peptide is a peptide that targets Hsp70.
V127992	A8 peptide	1140483-17-5	A8 peptide is an Hsp72 antagonist.
V113244	Aha1/Hsp90-IN-2		Aha1/Hsp90-IN-2 is a selective inhibitor of Hsp90/Aha1 interaction with an IC50 value of 1.46 μM.
V88684	AlF-NOTA-c-d-VAP		AlF-NOTA-cd-VAP is a peptide positron emission tomography (PET) probe for targeted tumor imaging of GRP78.
V128820	Androgen receptor degrader-6	1372688-55-5	Androgen receptor degrader-6 is an androgen receptor degrader that can cross the blood-brain barrier.
V120233	Antiproliferative agent-72	1052646-54-4	Antiproliferator-72 (compound 10) is an Hsp90 inhibitor with a Kd value of 11 nM.
V88685	AP-4-139B	2716909-84-9	AP-4-139B is a heat shock protein 70 (HSP70) inhibitor (IC50=180 nM).
V129217	Apatorsen sodium scrambled negative control		Apatorsen sodium scrambled negative control is a negative control with the Apatorsen sodium sequence scrambled.
V55768	Arimoclomol citrate (BRX-220 citrate)	368860-21-3	Arimoclomol citrate (BRX-220 citrate) is a heat shock protein (HSP) co-inducer.
V50992	AT-533	908112-37-8	AT-533 is a novel inhibitor of Hsp90 and HSV.
V0877	BIIB021	848695-25-0	BIIB021 (CNF2024;BIIB-021; CNF-2024; CNF 2024; BIIB 021) is an orally bioavailable and purine-based small-molecule inhibitor of HSP90 (heat shock protein 90) with potential anticancer activity.
V117131	BIIB021 mesylate	1225041-97-3	BIIB021 (CNF2024) methanesulfonate is a methanesulfonate derivative of BIIB021.
V73174	BX-2819	1184181-50-7	BX-2819 is an Hsp90 inhibitor (antagonist) with IC50 of 41 nM.
V98845	C086	1160107-44-7	C086 is a novel and potent Hsp90 inhibitor that inhibits cell cycle progression, induces apoptosis, and exerts anti-metastatic effects by regulating various mechanisms in different cell types.
V17743	CCT251236	1693731-40-6	CCT-251236, a chemical probe bisamide, is a novel, potent and orally bioavailable Pirin Ligand identified from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen (IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction).