Heat shock proteins (HSPs) are a class of functionally related proteins that are involved in the folding and unfolding of other proteins. HSPs are a group of proteins that are produced in response to heat shock. When cells are subjected to high temperatures or other stresses, HSP expression rises. This increase in expression is controlled by transcription. Heat shock factor (HSF) is primarily responsible for the dramatic upregulation of the heat shock proteins, which is a crucial component of the heat shock response. Nearly every living thing, from bacteria to people, contains HSPs. Heat shock proteins seem to play a big part in the cardiovascular system. There have been reports of the roles of Hsp90, Hsp84, Hsp70, Hsp27, Hsp20, and alpha B crystallin in the cardiovasculature.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V55770 | 17-DMAP-GA | 169521-68-0 | 17-DMAP-GA, an analog of Geldanamycin, is an HSP90 inhibitor and can cause cell cycle abnormalities. |
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V106607 | 2-Methoxyhydroquinone | 824-46-4 | 2-Methoxyhydroquinone is a phenolic compound that reduces TNF-α-induced chemokine (CC motif) ligand 2 (CCL2) production with an IC50 value of 64.3 µM. |
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V52504 | 3-Phenyltoxoflavin | 32502-63-9 | 3-Phenyltoxoflavin is an analogue of Toxoflavin and an Hsp90 inhibitor. |
![[Au(TPP)]Cl](http://www.invivochem.com/upload/1124/V89622.png)
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V89622 | [Au(TPP)]Cl | 15695-27-9 | [Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex and has anticancer activity. |
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V113244 | Aha1/Hsp90-IN-2 | Aha1/Hsp90-IN-2 is a selective inhibitor of Hsp90/Aha1 interaction with an IC50 value of 1.46 μM. | |
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V88684 | AlF-NOTA-c-d-VAP | AlF-NOTA-cd-VAP is a peptide positron emission tomography (PET) probe for targeted tumor imaging of GRP78. | |
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V120233 | Antiproliferative agent-72 | 1052646-54-4 | Antiproliferator-72 (compound 10) is an Hsp90 inhibitor with a Kd value of 11 nM. |
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V88685 | AP-4-139B | 2716909-84-9 | AP-4-139B is a heat shock protein 70 (HSP70) inhibitor (IC50=180 nM). |
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V55768 | Arimoclomol citrate (BRX-220 citrate) | 368860-21-3 | Arimoclomol citrate (BRX-220 citrate) is a heat shock protein (HSP) co-inducer. |
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V50992 | AT-533 | 908112-37-8 | AT-533 is a novel inhibitor of Hsp90 and HSV. |
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V117131 | BIIB021 mesylate | 1225041-97-3 | BIIB021 (CNF2024) methanesulfonate is a methanesulfonate derivative of BIIB021. |
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V98845 | C086 | 1160107-44-7 | C086 is a novel and potent Hsp90 inhibitor that inhibits cell cycle progression, induces apoptosis, and exerts anti-metastatic effects by regulating various mechanisms in different cell types. |
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V56157 | Cemdomespib (KU-596) | 1450642-92-8 | Cemdomespib (KU-596) is a potent second-generation Hsp90 modulator. |
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V114694 | Chaperone complex ligand 1 | 3048497-50-0 | Molecular chaperone complex ligand 1 is a molecular chaperone ligand for heat shock protein 90 (HSP90). |
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V103049 | Cholesterol β-D-glucoside | 7073-61-2 | Cholesterol β-D-glucoside (Cholesterol β-glucoside) is a heat shock transcription factor 1 (HSF1) activator. |
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V115009 | CliMB-325 | CliMB-325 is an HSP90 inhibitor that induces the expression of MHC-I on the surface of CT26 mouse colorectal cancer cells (EC50 = 498 nM). | |
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V52194 | DDO-5936 | 2355377-13-6 | DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. |
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V114989 | DDO-6600 | 2640292-37-9 | DDO-6600 is a covalent Hsp90 inhibitor. |
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V109664 | Dehydroherbarin | 36379-74-5 | Dehydroherbaline is a selective HSP90α inhibitor that can cross the blood-brain barrier. |
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V102658 | DN401 | 2135749-60-7 | DN401 is a potent TRAP1 inhibitor with IC50 of 79 nM. |
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