HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly.This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V55241 | (E,E)-RGFP966 | 1396841-57-8 | (E,E)-RGFP966 is a selective CNS-permeable/penetrable HDAC3 inhibitor that may be utilized to study Huntington's disease. |
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V121930 | (R)-HDAC-IN-102 | 1177382-00-1 | (R)-HDAC-IN-102 is an HDAC2 inhibitor and an isomer of HDAC-IN-102. |
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V122028 | (Rac)-Nanatinostat | 914937-68-1 | (Rac)-Nanatinostat is a potent HDAC inhibitor with an IC50 of <330 nM. |
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V122172 | (S)-HDAC-IN-102 | 748159-43-5 | (S)-HDAC-IN-102 is an HDAC8 inhibitor and an isomer of HDAC-IN-102. |
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V75838 | (S)-TNG260 | 2935964-93-3 | (S)-TNG260 is an isomer of TNG260. |
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V124890 | 2-Propylpent-4-ynoic acid | 24102-11-2 | 2-Propylpent-4-ynoic acid is a histone deacetylase (HDAC) inhibitor (IC50 for human HDAC is 0.5 mM). |
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V126511 | 4-Phenylcinnamic acid | 13026-23-8 | 4-Phenylcinnamic acid is a weak HDAC2 inhibitor (IC50 > 5 μM). |
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V4087 | UF010 | 537672-41-6 | UF010 (UF-010; UF 010) is a novel, potent and selective class I HDAC inhibitor with potential anticancer activities. |
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V41465 | 4-iodo-SAHA | 1219807-87-0 | 4-Iodo-SAHA (1k) is a class I and class II histone deacetylase (HDAC) inhibitor (antagonist) with EC50s of 1.1, 0.95, 0.12, 0.24, and 0.85 for Skbr3, HT29, U937, JA16, and HL60 cells, respectively. |
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V0284 | Sodium Phenylbutyrate (4-PBA sodium) | 1716-12-7 | Sodium phenylbutyrate (4-Phenylbutyric acid sodium; 4-PBA sodium),an orphan drug marketed by Ucyclyd Pharma, is a novel and potent histone deacetylase (HDAC) inhibitor used as an as adjunctive therapy for chronic treatment of urea cycle disorders involving deficiencies of argininosuccinic acid synthetase (AS), ornithine transcarbamylase (OTC), or carbamylphosphate synthetase (CPS). |
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V0264 | Domatinostat (4SC202) | 910462-43-0 | Domatinostat (formerly 4SC-202)is a novel, potent, and orally bioavailable benzamide-based Class I HDAC inhibitor with potential anticancer activity. |
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V53007 | 5-Phenylpentan-2-one (phenylbutyric acid; phenylbutyric acid) | 2235-83-8 | 5-Phenylpentan-2-one is a potent inhibitor of histone deacetylase enzymes (HDACs). |
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V52466 | 9-Hydroxyoctadecanoic acid (9-Hydroxystearic acid; 9-HSA) | 3384-24-5 | 9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that can suppress approximately 66.4% of HDAC1 enzymatic activity at 5 μM. |
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V104653 | AAK1/HDACs-IN-1 | AAK1/HDACs-IN-1 (Compound 12) is a dual inhibitor of AAK1 and HDAC, inhibiting AAK1, HDAC1, and HDAC6 with IC50 of 15.9, 148.6, and 5.2 nM, respectively. | |
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V128213 | Ac-QPKK(Ac)-AMC acetate | Ac-QPKK(Ac)-AMC acetate is a p53-derived peptide coupled with a fluorophore and can be used as a fluorescent peptide substrate for detecting zinc-dependent HDAC and sirtuins deacylation activities (excitation wavelength = 360 nm; emission wavelength = 460 nm). | |
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V97450 | Acefylline piperazine | 18833-13-1 | Acetylphylline piperazine is a xanthine derivative and adenosine receptor antagonist. |
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V2907 | ACY-738 | 1375465-91-0 | ACY-738 (ACY738) is a novel, potent, selective, brain penetrable and orally-bioavailable HDAC6 inhibitor with neuroprotective and anticancer activities. |
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V3772 | ACY-775 | 1375466-18-4 | ACY-775, anovel pyrimidine hydroxyl amide small molecule, is a brain bioavailable, highly potent and isoform-selective inhibitor of HDAC6 with IC50of 7.5 nM. |
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V2346 | AES-350 | 847249-57-4 | AES-350 is a potent orally bioactive HDAC6 inhibitor (antagonist) with IC50 and Ki of 0.0244 μM and 0.035 μM, respectively. |
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V89054 | ALK/HDAC-IN-1 | ALK/HDAC-IN-1 is a dual inhibitor of ALK and HDAC6 with IC50 of 16 nM and 1.03 μM, respectively. |
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