HDAC

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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HDAC

HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly.This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.

HDAC related products

Cat No.	Product Name	CAS No.	Product Description
V103728	Martinostat	1629052-58-9	Martinostat is an HDAC inhibitor that can be radionuclide-labeled to allow quantitative imaging of HDAC in the central nervous system and major peripheral organs in vivo.
V85807	Martinostat hydrochloride
V102688	MD 85	193551-00-7	MD 85 is a potent histone deacetylase (HDAC) inhibitor with EC50 of 5 μM.
V104674	Naph-Se-TMZ		Naph-Se-TMZ is a PROTAC-like HDAC1 degrader that can reduce total HDAC activity in glioma cells and enhance the inhibitory effect of temozolomide.
V101114	NT376	2820208-97-5	NT376 is a potent and selective class IIa histone deacetylase (HDAC) inhibitor with IC50 of 32 nM, similar to NT160 (IC50= 46 nM) in HT-29 cells.
V88673	PARP7/HDACs-IN-1		PARP7/HDACs-IN-1 (compound 9l) is a dual-target inhibitor targeting PARP7/HDAC with anti-tumor activity.
V85810	PB118
V94362	PB200		PB200 is a HDAC6 inhibitor with IC50 of 1.97 nM.
V27646	Pivanex	122110-53-6	Pivanex (AN-9; AN 9; AN9; pivaloyloxymethyl butyrate; Titan) is a novel and potent histone deacetylase/HDAC inhibitor with anticancer and antiangiogenic properties.
V99855	PROTAC HDAC8 Degrader-1		PROTAC HDAC8 Degrader-1 (Compound Z16) is a potent and selective HDAC8 PROTAC degrader with a DC50 of 0.27 nM in A549 cells.
V93713	PROTAC HDAC8 Degrader-2		PROTAC HDAC8 Degrader-2 (compound 32a) is a degrader of HDAC8 with a DC50 of 8.9 nM and a degrader of HDAC6 with a DC50 of 14.3 nM.
V103367	Purinostat	1929583-17-4	Purinostat is a selective HDAC I/IIb inhibitor with anti-leukemic activity.
V93038	ROCK/HDAC-IN-1		ROCK/HDAC-IN-1 (Compound 10h) is an orally available ROCK/HDAC inhibitor.
V87880	SAP15	1403753-45-6	SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide composed of 15 amino acids designed from human β-defensin 3.
V88666	SE-7552	2243575-79-1	SE-7552 is a 2-(difluoromethyl)-1,3,4-oxadiazole (DFMO) derivative and is an orally active, highly selective, non-hydroxamic acid HDAC6 inhibitor with an IC50 of 33 nM.
V89011	sEH/HDAC6-IN-2	3009011-58-6	sEH/HDAC6-IN-2 is a potent dual soluble epoxide hydrolase (sEH) and HDAC6 inhibitor with IC50 of 0.9 nM, 46.8 nM and 8 nM for human sEH, mouse sEH and HDAC6, respectively.
V88670	SelSA	1225038-92-5	SelSA is an orally available, selective inhibitor of histone deacetylase 6 (HDAC6) with an IC50 of 56.9 nM.
V98214	STAT3/HDAC-IN-2		STAT3/HDAC-IN-2 (compound 18) is a dual inhibitor of STAT3 and HDAC that induces autophagy and apoptosis.
V88864	STR-V-53	2798954-66-0	STR-V-53 is a HDAC inhibitor (IC50 in nM).
V4636	SW-100	2126744-35-0	SW-100 (SW100),a tetrahydroquinoline-based compound, is a novel, potent, brain penetrant and selectivehistone deacetylase 6 (HDAC6)inhibitor (IC50 = 2.3 nM) with neuroprotective effects.