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Eukaryotic Initiation Factor

Eukaryotic Initiation Factor

Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation.These proteins offer regulatory mechanisms for translation initiation as well as aid in stabilizing the formation of the functional ribosome around the start codon.

A guanine nucleotide-exchange protein called eukaryotic initiation factor 2B (eIF2B) facilitates the conversion of GDP (bound to eIF2) into GTP, thereby regenerating the active [eIF2.GTP] complex necessary for peptide chain initiation. An important regulator of eukaryotic protein synthesis, eIF2B activity changes in response to viral infection, hormones, nutrients, growth factors, and specific stresses.

The role of eukaryotic translation initiation factor 4E (eIF4E) in the beginning of protein synthesis on capped mRNAs in the cytoplasm is well known. The initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome, is composed of the eukaryotic initiation factor (elF) 4A as a subunit.

Eukaryotic Initiation Factor related products

Structure Cat No. Product Name CAS No. Product Description
(Z)-4EGI-1 V52830 (Z)-4EGI-1 901787-88-0 (Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor (blocker/antagonist) of eIF4E/eIF4G interaction and translation initiation.
1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea V111252 1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea 3824-74-6 1,3-Bis[3,5-Bis(trifluoromethyl)phenyl]urea is a potent activator of the eIF2α kinase heme-regulating inhibitor.
2BAct V11588 2BAct 2143542-28-1 2BAct is a novel, potent,highly selective, CNS-permeable, and orally bioactive eif2b (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM, it prevents neurological defects caused by a chronic integrated stress response (ISR).
4E1RCat V1946 4E1RCat 328998-25-0 4E1RCat is a potent and dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 protein-protein interaction, and also inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.
4EGI-1 V1959 4EGI-1 315706-13-9 4EGI-1 is a potent and competitive eIF4E/eIF4G interaction inhibitor which binds to eIF4E with KD of 25 μM.
AMG-34 V118246 AMG-34 1644664-11-8 AMG-34 is a target of GCN2, with IC50 values of 0.395 μM, 0.010 μM, 1.07 μM, and >10 μM for GCN2, PERK, HRl, and PKR, respectively.
APL-4098 V129271 APL-4098 2752441-61-3 APL-4098 is an orally effective selective ATP-competitive GCN2 inhibitor with a Ki value of 4.39 nM and a Kd value of 2.9 nM.
ATF4-IN-1 V103552 ATF4-IN-1 2991057-76-0 ATF4-IN-1 (Compound 21) is an ATF4 inhibitor and eIF2B activator.
Bemiltenase alfa V129989 Bemiltenase alfa 2766038-73-5 Bemiltenase alfa is a hemostatic agent that targets coagulation factor X (FX).
BMS-962212 hydrochloride V130402 BMS-962212 hydrochloride 1430115-97-1 BMS-962212 hydrochloride is a selective factor XIa inhibitor and an acute antithrombotic drug.
Briciclib sodium V112098 Briciclib sodium 865784-01-6 Buliximab (ON 014185) is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor.
Cenvacibart V131377 Cenvacibart 3008610-21-4 Cenvacibart is a monoclonal antibody with anticoagulant activity that targets human coagulation factor XI (F11).
CMLD012072 V55219 CMLD012072 2368900-33-6 CMLD012072 is an amidino-rocaglates and a potent inhibitor of eukaryotic initiation factor 4A (eIF4A).
CMLD012073 V18324 CMLD012073 2368900-32-5 CMLD012073 is an amidino-rocaglates and a potent inhibitor of eukaryotic initiation factor 4A (eIF4A).
CMLD012612 V52239 CMLD012612 2368900-35-8 CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor.
Comtifator V132044 Comtifator 2518151-57-8 Comtifator is a regulator that integrates stress response pathways.
DMDA-PatA V96731 DMDA-PatA 1531593-48-2 DMDA-PatA is a small-molecule eIF4A inhibitor that inhibits translation by clamping eIF4A, a DEAD-box RNA-binding protein, onto the GNG motif in an mRNA-selective and ATP-independent manner.
DNL-343 V55207 DNL343 2278265-85-1 DNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that can inhibit the abnormal integrated stress response (ISR).
EIF2AK4 Recombinant Human Active Protein Kinase V118787 EIF2AK4 Recombinant Human Active Protein Kinase EIF2AK4, a recombinant human active protein kinase, belongs to a class of kinases whose members regulate angiogenesis in cellular stress responses and can be used to study pulmonary capillary hemangioma (PCH).
EIF2B-IN-1 V115255 EIF2B-IN-1 EIF2B-IN-1 (compound A) is an eIF2B inhibitor.
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