| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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Purity: ≥98%
| Targets |
AP-1; c-Myc
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|---|---|
| ln Vitro |
In whole-cell experiments, Mycro 3 is a strong and sensitive c-Myc dye that exhibits a mild inhibitory effect against activator protein 1 (AP-1). The dye-reactive properties of Mycro 3 are identical to those of its predecessor. Mycro 3 prevents Myc and Max from coordinating with the c-Myc dye. Mycro 3 is a highly specific inhibitor of DNA binding and c-Myc/Max dimerization [1]. With IC50s of 0.25 and 9.0 μM for cells with intact Myc alleles and Myc-null cells, respectively, Mycro 3 shows excellent promise [2].
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| ln Vivo |
In patients with pancreatic ductal adenocarcinoma (PDA), Mycro 3 (100 mg/kg; oral; taken daily for two months) significantly reduces cell swelling, enlarges the pancreas, and causes considerable shrinking. Significant differences were also observed in the growth of Mycro 3-treated NOD/SCID tumors containing orthotopic or heterotopic human pancreatic xenografts [2].
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| Animal Protocol |
Animal/Disease Models: Moribund Pdx1-cre/KRAS* mice with pancreatic ductal adenocarcinoma (PDA) [2]
Doses: 100 mg/kg Route of Administration: Oral; one time/day for two months Experimental Results: Prolonged survival . Mycro 3 administration was stopped after two months, and the mice survived for another month. |
| References |
[1]. Chen BJ, et al. Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci. 2014 Sep 13;10(10):1084-96.
[2]. Dimitris Stellas, et al. Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer. J Natl Cancer Inst. 2014 Oct 11;106(12):dju320. |
| Molecular Formula |
C24H17CLF2N6O4
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|---|---|
| Molecular Weight |
526.88
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| Exact Mass |
526.0968
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| Elemental Analysis |
C, 54.71; H, 3.25; Cl, 6.73; F, 7.21; N, 15.95; O, 12.15
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| CAS # |
944547-46-0
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| Related CAS # |
944547-46-0
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| Appearance |
Solid powder
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| SMILES |
CCOC(=O)C1=C(N(N=C1)C2=CC=CC=C2)NC(=O)C3=NN4C(=CC(=NC4=C3)C5=CC=CO5)C(F)(F)Cl
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| InChi Key |
YPPNLSKYXDXQGD-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C24H17ClF2N6O4/c1-2-36-23(35)15-13-28-32(14-7-4-3-5-8-14)21(15)30-22(34)17-12-20-29-16(18-9-6-10-37-18)11-19(24(25,26)27)33(20)31-17/h3-13H,2H2,1H3,(H,30,34)
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| Chemical Name |
ethyl 5-[[7-[chloro(difluoro)methyl]-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]-1-phenylpyrazole-4-carboxylate
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| Synonyms |
Mycro3; Mycro-3; Mycro 3
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~189.8 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (4.74 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8980 mL | 9.4898 mL | 18.9797 mL | |
| 5 mM | 0.3796 mL | 1.8980 mL | 3.7959 mL | |
| 10 mM | 0.1898 mL | 0.9490 mL | 1.8980 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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