TAM receptors, comprising of Tyro3, Axl and Mertk receptors, are receptor tyrosine kinases (RTKs) that are expressed by multiple immune cells including NK cells.The mature immune, nervous, and reproductive systems depend on the TAM family of receptors and their ligands, Gas6 and Protein S (PROS1), for the best phagocytosis of apoptotic cells.
Three homologous type I receptor-tyrosine kinases known as TAMs are triggered by PROS1 and GAS6, two endogenous ligands. These ligands can either act as soluble factors to activate TAMs or act as connecting molecules between TAMs and apoptotic cells (ACs) by opsonizing phosphatidylserine (PS) on ACs. Cancer cell survival and proliferation as well as the suppression of anti-tumor immunity have been linked to abnormal TAM expression and activation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0637 | UNC2881 | 1493764-08-1 | UNC2881 (UNC-2881) is a novel, potent and specific Mer tyrosine kinase inhibitor with potential utility for prevention and treatment of pathologic thrombosis. |
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V69248 | UNC5293 | 2226789-82-6 | UNC5293 is a selective inhibitor of MERTK (Ki=190 pM). |
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V5018 | UNC569 | 1350547-65-7 | UNC569 is a novel, potent and selective small-molecule MER inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. |
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V2387 | Zanzalintinib (XL092) | 2367004-54-2 | Zanzalintinib (XL092) is an orally bioactive, ATP-competitive inhibitor of multiple receptor tyrosine kinases (RTKs) like MET, VEGFR2, AXL, and MER, with IC50s of 15 nM and 1.6, respectively, in cell assays nM, 3.4 nM and 7.2 nM. |
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