My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    UNC2881
    UNC2881

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V0637
    CAS #: 1493764-08-1Purity ≥98%

    Description: UNC2881 (UNC-2881) is a novel, potent and specific Mer tyrosine kinase inhibitor with potential utility for prevention and treatment of pathologic thrombosis. It inhibits Mer with an IC50 of 4.3 nM, and shows 83- and 58-fold higher selectivity over Axl and Tyro3, respectively. The role of Mer kinase in regulating the second phase of platelet activation generates an opportunity to use Mer inhibitors for preventing thrombosis with diminished likelihood for bleeding as compared to current therapies. 

    References: J Med Chem. 2013 Dec 12;56(23):9693-700.

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)463.58
    FormulaC25H33N7O2
    CAS No.1493764-08-1
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 292 mg/mL (198.5 mM)   
    Water: <1 mg/mL
    Ethanol: 5 mg/mL (10.8 mM)
    Other info
    Chemical Name: N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide
    InChi Key: NPVXOWLPOFYACO-XUTJKUGGSA-N
    InChi Code: InChI=1S/C25H33N7O2/c1-2-3-12-27-25-29-16-22(23(31-25)30-19-6-10-21(33)11-7-19)24(34)28-15-18-4-8-20(9-5-18)32-14-13-26-17-32/h4-5,8-9,13-14,16-17,19,21,33H,2-3,6-7,10-12,15H2,1H3,(H,28,34)(H2,27,29,30,31)/t19-,21-
    SMILES Code: O=C(C1=CN=C(NCCCC)N=C1N[[email protected]]2CC[[email protected]](O)CC2)NCC3=CC=C(N4C=CN=C4)C=C3 
    SynonymsUNC-2881, UNC 2881, UNC2881, 


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: UNC2881 inhibits Mer kinase activity in 697 B-ALL cells with IC50 of 22 nM, and inhibits collagen-stimulated platelet aggregation.


    Kinase Assay: UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM.


    Cell Assay: In 697 B-ALL cells, UNC2881 inhibited Mer phosphorylation with IC50 value of 22 nM. Also, UNC2881 inhibited ligand-dependent phosphorylation of a chimeric protein consisting of the intracellular domain of Mer and the extracellular domain of the epidermal growth factor receptor (EGFR). In human platelet-rich plasma, UNC2881 inhibited platelet aggregation induced by fibrillar Type I equine collagen by greater than 25%. UNC2881 also inhibited ATP release, a marker of platelet activation.

    In VivoUNC2881 have high systemic clearance (94.5 mL/min/kg) and 14% oral bioavailability in mice.
    Animal modelMouse model
    Formulation & Dosage94.5 mL/min/kg; oral
    ReferencesJ Med Chem. 2013 Dec 12;56(23):9693-700.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    UNC2881

    UNC2881 (compound 23) inhibits endogenous Mer tyrosine kinase activation in acute lymphoblastic leukemia cells. J Med Chem. 2013 Dec 12;56(23):9693-700.

    UNC2881


    UNC2881

    23 inhibits ligand-stimulated activation of a chimeric EGFR-MerTK. J Med Chem. 2013 Dec 12;56(23):9693-700.

    UNC2881

    23 inhibits collagen-stimulated platelet aggregation. J Med Chem. 2013 Dec 12;56(23):9693-700.


    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?