Src family kinase (SFK) is a family of non-receptor tyrosine kinases including nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily.Src-family kinases (SFKs) have been identified as important immune cell regulators of numerous intracellular signaling pathways. Src-family kinases (SFKs) participate in a number of signaling transduction cascades, including those originating from integrins, growth factor receptors, T and B cell antigen receptors, and Fc receptors. Src-family kinases (SFKs) can play both positive and negative regulatory roles in cellular signaling.By phosphorylating immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on inhibitory receptors, they can attract and activate inhibitory molecules like the phosphatases SHP-1 and SH2 containing 5′ inositol phosphatase (SHIP-1) and act as negative regulators of cellular signaling.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V69770 | Osteogenic Growth Peptide (10-14) (OGP(10-14); Historphin) | 105250-85-9 | Osteogenic Growth Peptide (10-14) (OGP(10-14)) is a C-terminal truncated pentapeptide of osteogenic growth peptide (OGP) that retains intact OGP-like activity. |
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V69765 | Saracatinib difumarate (AZD0530 difumarate) | 893428-72-3 | Saracatinib (AZD0530) difumarate is a potent Src inhibitor (antagonist) with IC50s of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. |
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V12161 | Scutellarein | 529-53-3 | Scutellarein is a naturally occurring flavonoid compound with anti~inflammatory effects. |
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V69769 | Squarunkin A | 2101958-02-3 | Squarunkin A is a potent and specific inhibitor of UNC119-Cargo interaction that can inhibit the interaction of UNC119A with myristoylated Src N-terminal peptide (IC50=10 nM). |
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V69774 | Squarunkin A hydrochloride | 2253744-55-5 | Squarunkin A HCl is a potent and specific inhibitor of UNC119-Cargo interaction, inhibiting the interaction of UNC119A with myristoylated Src N-terminal peptide (IC50=10 nM). |
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V69767 | Src Inhibitor 3 | 2380027-49-4 | Src Inhibitor 3 is a potent, orally bioactive c-terminal Src kinase (CSK) with IC50s of less than 3 nM and 4 nM in CSK HTRF and Caliper assays, respectively. |
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V5008 | TG 100572 HCl | 867331-64-4 | TG 100572 HCl (TG-100572; TG100572), the hydrochloride salt of TG100572, is a novel, potent and selective multi-targeted kinase (receptor tyrosine kinases and Src kinases) inhibitor with anti-proliferative activity and is being developed forthe treatment of AMD (age-related macular degeneration). |
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V4266 | Tirbanibulin dihydrochloride | 1038395-65-1 | Tirbanibulin dihydrochloride (also known as KXO1 dihydrochloride and KX2-391 dihydrochloride) is a dual Src/tubulin inhibitor approved in 2020 for the treatment of actinic keratosis on the face or scalp. |
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V4267 | Tirbanibulin Mesylate | 1080645-95-9 | Tirbanibulin Mesylate (also known as KXO-1 Mesylate and KX2-391 Mesylate) is a tubulin/Src inhibitor that has gained FDA approval in 2020for the treatment of actinic keratosis on the face or scalp. |
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V16561 | Tolimidone (MLR-1023) | 41964-07-2 | Tolimidone, formerly known as MLR-1023, is a novel and potent insulin receptor potentiator, and also a selective allosteric activator of Lyn kinase(EC50 of 63 nM). |
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V69776 | Tyrosine Kinase Peptide 1 | 173691-86-6 | Tyrosine Kinase Peptide 1 is the control substrate used in c-Src kinase experiments. |
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