| Size | Price | |
|---|---|---|
| 100mg | ||
| 250mg | ||
| 500mg |
| Targets |
shp2 (IC50 = 0.318 μM); shp1 (IC50 = 0.355 μM)
|
|---|---|
| ln Vitro |
NSC-87877 (0-0.5 μM, 5 days) blocks DUSP26 activity in NB cell lines[3].
NSC-87877 (0-0.5 μM, 5 days) causes an increase in the activation and phosphorylation of p53 at Ser37 and Ser46[3]. |
| ln Vivo |
NSC-87877 (30 mg/kg, IP once daily for 15 days) has strong anti-neuroblastoma properties[3].
|
| Animal Protocol |
Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice[3].
30 mg/kg. IP once daily for 15 days. |
| References |
|
| Molecular Formula |
C19H11N3NA2O7S2
|
|---|---|
| Molecular Weight |
503.416
|
| Exact Mass |
502.98
|
| Elemental Analysis |
C, 45.33; H, 2.20; N, 8.35; Na, 9.13; O, 22.25; S, 12.74
|
| CAS # |
56932-43-5
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| Related CAS # |
NSC-87877;56990-57-9
|
| Appearance |
Solid
|
| SMILES |
C1=CC2=C(C=C(C(=C2N=C1)O)N=NC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+]
|
| InChi Key |
IFVGQKHFUZRWNA-UHFFFAOYSA-L
|
| InChi Code |
InChI=1S/C19H13N3O7S2.2Na/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13;;/h1-10,23H,(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2
|
| Chemical Name |
disodium;8-hydroxy-7-[(6-sulfonatonaphthalen-2-yl)diazenyl]quinoline-5-sulfonate
|
| Synonyms |
NSC87877 disodium; NSC 87877 disodium; NSC 87877; NSC-87877; NSC.87877; NSC87877
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100~125 mg/mL (198.6~248.3 mM)
Water: ~100 mg/mL (~198.6 mM) |
|---|---|
| Solubility (In Vivo) |
2% DMSO+35% PEG 300+2% Tween 80+ddH2O: 6mg/mL (Please use freshly prepared in vivo formulations for optimal results.)
|
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9864 mL | 9.9321 mL | 19.8641 mL | |
| 5 mM | 0.3973 mL | 1.9864 mL | 3.9728 mL | |
| 10 mM | 0.1986 mL | 0.9932 mL | 1.9864 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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