FLT3 (Fms-like tyrosine kinase 3, CD135) is a protein that in humans is encoded by the FLT3 gene.The class III receptor tyrosine kinase family includes FLT3, a cytokine receptor. FLT3 is the cytokine Flt3 ligand (FLT3L)'sreceptor. On the surface of many hematopoietic progenitor cells, FLT-3 is expressed. The normal development of hemopoietic stem cells and progenitor cells depends on FLT3 signaling. One of the genes with the highest frequency of mutations in acute myeloid leukemia (AML) is FLT3.Furthermore, high FLT3 levels in blast cells from some AML patients without FLT3 mutations have been observed. The prognosis may be worse when these levels are high. Cell proliferation, differentiation, and survival are influenced by FLT3 signaling. FLT3 is crucial for the growth of lymphocytes (B and T cells), but not for the growth of other blood cells. The cytokines TNF-Alpha and TGF-Beta both inhibit FLT3 activity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V2881 | SKLB4771 | 1370256-78-2 | SKLB4771 (also known as FLT3-IN-1) is a novel, potent and selective inhibitor of FLT3 (fms-like tyrosine kinase 3) that may be potentially used for the treatment of cutaneous inflammation and psoriasis-like symptoms of disease. |
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V0583 | Tamatinib besylate (R406) | 841290-81-1 | Tamatinib besylate (formerly R-406 besylate; prodrug of R 406) is a novel, potent and ATP-competitive inhibitor of spleen tyrosine kinase/Syk with potential anti-inflammatory activity. |
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V0585 | Tandutinib (MLN518, CT53518, NSC-726292) | 387867-13-2 | Tandutinib (formerly also known as MLN-518, CT-53518, D06005, NSC726292), a piperazinyl quinazoline, is a novel, potent and selective FLT3 inhibitor/antagonist with potential antitumor activity. |
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V0589 | TCS 359 | 301305-73-7 | TCS 359 (TCS-359) is a novel, ATP-competitive and selective fms-like/FLT3 kinase inhibitor with IC50 of 42 nM. |
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V2549 | UNC-2025 | 1429881-91-3 | UNC-2025 is a novel,potent and orally bioavailable dualinhibitor of MER/FLT3 with IC50 of 0.74 nM and 0.8 nM, respectively, itdisplayed about 20-fold selectivity over Axl and Tyro3. |
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V0586 | UNC-2025 HCl | 2070015-17-5 | UNC-2025 HCl (known also as UNC2025), the Hydrochloride salt of UNC-2025,is an orally bioavailable and selective MER/FLT3 dualinhibitor with potential antineoplastic activity. |
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