Keap1-Nrf2 is the major regulator of cytoprotective responses to electrophilic chemicals or reactive oxygen species (ROS).Keap1 is an E3 ligase that triggers the ubiquitin-proteasome system (UPS) to degrade Nrf2. In cancer cells, upregulation of Nrf2 induced by Keap1 inactivation is frequently seen. Cancer cells' metabolism and proliferation are accelerated by aberrant Nrf2 activation. In this instance, Nrf2 is a desirable molecule to target therapeutically for the treatment of cancer, and numerous Nrf2 inhibitors are being developed. What's interesting is that Nrf2 induction is reportedly used as a treatment strategy to quicken the body's carcinogen detoxification process and prevent chemical carcinogenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V82250 | (S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) | 2341796-79-8 | (S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VH032-based VHL ligand and 1 linker. |
|
V82232 | 25-Hydroxycholesterol-d6 (25-Hydroxycholesterol-d6) | 88247-69-2 | 25-Hydroxycholesterol-d6 is the deuterated form of 25-Hydroxycholesterol. |
|
V31615 | Methyl 3,4-dihydroxybenzoate | 2150-43-8 | Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) is the primary metabolite of antioxidant polyphenols found in green tea. |
|
V109532 | 3-Hydroxyphenylacetic acid-d6 | 3-Hydroxyphenylacetic acid-d6 is a deuterated derivative of 3-hydroxyphenylacetic acid. | |
|
V82248 | 3-Methylhistamine dihydrochloride | 36475-47-5 | 3-Methylhistamine di-HCl is a degradation product of histamine. |
|
V109503 | 4-Hydroxyphenylacetic acid-d2 | 4-Hydroxyphenylacetic acid-d2 is a deuterated derivative of 4-hydroxyphenylacetic acid. | |
|
V110821 | 4-Octyl itaconate-Bn-S-NH2 | 4-Octylitaconate-Bn-S-NH2 (compound 8b) is a vasodilator. | |
|
V82236 | 9,10-Dimethoxycanthin-6-one | 155861-51-1 | 9,10-Dimethoxycanthin-6-one is an alkaloid compound that can inhibit NF-κB with IC50 of 19.5 μM. |
|
V82237 | 9-Hydroxycanthin-6-one | 138544-91-9 | 9-Hydroxycanthin-6-one is an alkaloid compound that can inhibit NF-κB with IC50 of 3.8 μM. |
|
V82244 | AP-1/NF-κB activation inhibitor 1 | 188936-12-1 | AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB-mediated transcription activation (IC50=1 μM) and does not block basal transcription driven by the β-actin promoter. |
|
V82231 | Coenzyme Q6 (Ubiquinone 30) | 1065-31-2 | Coenzyme Q6 (Ubiquinone 30) is a prenylated benzoquinone lipid. |
|
V107824 | CPDT | 14085-33-7 | CPDT is an orally available, potent phase 2 enzyme inducer and Nrf2 activator. |
|
V89041 | Fraxinellone analog 1 | Fraxinellone analog 1 (compound 2) is an effective and rapid activator of the Nrf2-mediated antioxidant defense system, which has a protective effect on glutamate-mediated excitotoxicity and induces the expression of antioxidant genes Gpx4, Sod1 and Nqo1. | |
|
V82253 | Ginger extract | 84696-15-1 | Ginger extract has anticancer, anti~inflammatory, and chemotherapeutic effects in animal models. |
|
V111209 | Ginnalin A | 76746-56-0 | Acertannin is an Nrf2 activator. |
|
V82238 | Goshonoside F5 | 90851-28-8 | Goshonoside F5 can be extracted from the immature fruits of Rubus chingii. |
|
V82251 | Gossypin | 652-78-8 | Gossypin is a flavonoid extracted from Hibiscus vitifolius and has antioxidant, anti-inflammatory, anti-cancer, anti-aging, anti-diabetic and liver-protective activities. |
|
V108379 | Gymnoside II | 899430-02-5 | Glucosinolate II is one of the main active ingredients in Bletilla striata extract. |
|
V82241 | Itaconic acid (Itaconic acid; Methylenesuccinic acid) | 97-65-4 | Itaconic acid is a precursor to synthetic polymers, chemicals and fuels that can be synthesized by fungi. |
|
V104958 | Keap1-IN-1 | Keap1-IN-1 (compound 27) is an inhibitor of Keap1 that interferes with Keap-Nrf interaction by covalently modifying the Cys151 site on the BTB domain of KEAP1. |
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