Keap1-Nrf2 is the major regulator of cytoprotective responses to electrophilic chemicals or reactive oxygen species (ROS).Keap1 is an E3 ligase that triggers the ubiquitin-proteasome system (UPS) to degrade Nrf2. In cancer cells, upregulation of Nrf2 induced by Keap1 inactivation is frequently seen. Cancer cells' metabolism and proliferation are accelerated by aberrant Nrf2 activation. In this instance, Nrf2 is a desirable molecule to target therapeutically for the treatment of cancer, and numerous Nrf2 inhibitors are being developed. What's interesting is that Nrf2 induction is reportedly used as a treatment strategy to quicken the body's carcinogen detoxification process and prevent chemical carcinogenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V51566 | Nrf2/HO-1 activator 2 | 2883506-31-6 | Nrf2/HO-1 activator |
|
V1892 | Oltipraz (RP 35972; NSC 347901) | 64224-21-1 | Oltipraz(RP 35972; NSC 347901), a potential anticancer agent, is a potent Nrf2 activator and an inducer of Phase II detoxification enzymes such asglutathione-S-transferase (GST). |
|
V1891 | Omaveloxolone (RTA-408) | 1474034-05-3 | Omaveloxolone (formerly known as RTA-408; Skyclarys; RTA408),an antioxidant inflammation modulator (AIM), is a 2nd generation member of the synthetic triterpenoid that can activate Nrf2 (a cytoprotective transcription factor) and inhibit NF-κB signaling. |
|
V82242 | Ovalbumins (ovalbumin) | 9006-59-1 | Ovalbumins are the major proteins found in egg whites and possess a variety of bioactivities such as anticancer, antihypertensive, antimicrobial, antioxidant, and immunomodulatory activities. |
|
V51652 | Rosolic Acid | 603-45-2 | activator of Nrf2 |
|
V82243 | Sappanone A | 102067-84-5 | Sappanone A is a high isoflavanone that displays anti-inflammatory effects by regulating Nrf2 and NF-κB. |
|
V82240 | SCH-202676 hydrobromide | 265980-25-4 | SCH-202676 HBr is a modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). |
|
V82247 | SDMA-d6 (Symmetric dimethylarginine-d6; NG,NG'-Dimethyl-L-arginine-d6) | 1331888-08-4 | SDMA-d6 is the deuterium labelled form of SDMA. |
|
V82246 | Sodium aescinate (sodium aescinate) | 20977-05-3 | Sodium aescinate is a triterpenoid saponin derived from Aesculus hippocastanum seeds, which has anti-inflammatory and antioxidant activities. |
|
V82233 | Stipuleanoside R2 | 96627-72-4 | Stipuleanoside R2 has a dose-dependent effect on the activation of NF-κB stimulated by TNFα, and its IC50 is 4.1μM. |
|
V82234 | Tagitinin F | 59979-57-6 | Tagitinin F is a sesquiterpene with potent anti-inflammatory activities and NF-κB inhibitory effects. |
|
V82249 | Taurocholic acid-d4 sodium (N-Choloyltaurine-d4 (sodium)) | 2410279-93-3 | Taurocholic acid-d4 (sodium) is the deuterated form of Taurocholic acid. |
|
V82245 | TGN-020 sodium | 1313731-99-5 | TGN-020 sodium is a selective aquaporin 4 (AQP4) inhibitor (antagonist) with IC50 of 3.1 μM. |
|
V82252 | Thalidomide-5-NH2-CH2-COOH | 2412056-27-8 | Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and specific inhibitor of tropomyosin receptor kinase (trk). |
|
V82239 | Urease-IN-10 | 1012205-70-7 | Urease-IN-10 (Conjugate 4) is a competitive Urease inhibitor (antagonist) with IC50 of 3.59±0.07 μM and a Ki of 7.45 μM. |
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