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    AZD3264
    AZD3264

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0756
    CAS #: 1609281-86-8Purity ≥98%

    Description: AZD3264 (AZD-3264; AZD 3264) is a novel and potent inhibitor of IKK2 (IkappaB Kinase/(IκB) with potential anti-inflammatory and anticancer activity. IKK2 is an enzyme complex that is a component of the NF-kappaB/NF-κB signaling pathway. AZD3264 is currently under preclinical development for treating inflammatory diseases including asthma, chronic pulmonary obstructive disorder (COPD) and RA/rheumatoid arthritis. Suppression of IKK2 has been identified as a potential therapeutic option to treat cancer and inflammatory diseases.

    References: Org. Process Res. Dev. 2014, 18, 646−651.

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    Molecular Weight (MW)441.5
    FormulaC21H23N5O4S
    CAS No.1609281-86-8
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 88 mg/mL (199.3 mM)
    Water: <1 mg/mL
    Ethanol: 2 mg/mL (4.5 mM)
    Other InfoChemical Name: 2-(Carbamoylamino)-5-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(3S)-pyrrolidin-3-yloxy]phenyl]thiophene-3-carboxamide
    InChi Key: NMFIXEFNQPDISY-ZDUSSCGKSA-N
    InChi Code: InChI=1S/C21H23N5O4S/c1-10-18(11(2)30-26-10)12-3-4-14(16(7-12)29-13-5-6-24-9-13)17-8-15(19(22)27)20(31-17)25-21(23)28/h3-4,7-8,13,24H,5-6,9H2,1-2H3,(H2,22,27)(H3,23,25,28)/t13-/m0/s1
    SMILES Code: O=C(C1=C(NC(N)=O)SC(C2=CC=C(C3=C(C)ON=C3C)C=C2O[[email protected]@H]4CNCC4)=C1)N
    SynonymsAZD-3264; AZD3264; AZD 3264; 


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    In Vitro

    In vitro activity: AZD3264, by inhibiting IKK2, was currently in preclinical development for the potential treatment of inflammatory diseases such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis.


    Cell Assay: 1AZD3264, by inhibiting IKK2, was currently in preclinical development for the potential treatment of inflammatory diseases such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis.

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    ReferencesOrg. Process Res. Dev. 2014, 18, 646−651.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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