STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The Janus kinase family of transcription factors is activated, and dysregulation of this pathway, which promotes angiogenesis, tumor survival, and immunosuppression, is frequently seen in primary tumors. Gene knockout studies have shown that STAT proteins are important for immune system development and operation, immune tolerance maintenance, and tumor surveillance.Initially, STAT proteins were thought to be dormant cytoplasmic transcription factors that needed to be phosphorylated in order to be retained in the nucleus. While awaiting an activation signal, the unphosphorylated STAT proteins move back and forth between the cytosol and the nucleus. The transcription of cytokine-inducible genes is activated once the activated transcription factor enters the nucleus and binds to the consensus DNA-recognition motif known as gamma-activated sites (GAS) in the promoter region.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V31841 | STAT3-IN-1 | 2059952-75-7 | STAT3-IN-1 is a novel, oral and selective STAT3 inhibitor with anticancer activity. |
|
V69155 | STAT3-IN-17 | 1245814-52-1 | STAT3-IN-17 is a moderate STAT3 inhibitor (IC50=0.7 μM; HEK-Blue IL-6) that displays antiproliferation activity in HeLa cells. |
|
V69147 | STAT3-IN-20 | 2768427-54-7 | STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50= 0.65 μM). |
|
V69148 | STAT3-IN-23 | 286465-26-7 | STAT3-IN-23 (PY*LKTK) is a potent STAT3 inhibitor. |
|
V69145 | STAT3-IN-24, cell-permeable (PpYLKTK-mts; STAT3 PI) | 400628-16-2 | STAT3-IN-24, cell-permeable (penetrable) (PpYLKTK-mts) is a STAT3 peptide inhibitor. |
|
V3230 | STAT5-IN-1 | 285986-31-4 | STAT5-IN-1 (also known as STAT5 Inhibitor) is aSTAT5 (signal transducer and activator of transcription 5) inhibitor with anticancer activity. |
|
V69142 | STAT6-IN-2 | 1355594-85-2 | STAT6-IN-2 (Comp R-84) is a STAT6 inhibitor. |
|
V69137 | STAT6-IN-3 | 371919-80-1 | STAT6-IN-3 (Compound 18a) is a STAT6 inhibitor (IC50= 44 nM). |
|
V69161 | YM-341619 (AS1617612) | 643082-52-4 | YM-341619 (AS1617612) is a potent oral STAT6 inhibitor (antagonist) with IC50 of 0.70 nM. |
|
V18077 | Golotimod (SCV07) | 229305-39-9 | Golotimod (Orilotimod, SCV-07), is a potent and orally bioavailable synthetic peptide with an immunomodulating and antimicrobial activities. |
|
V2259 | Narciclasine | 29477-83-6 | Narciclasine is a plant growth regulator. |
|
V4972 | Cucurbitacin I | 2222-07-3 | Cucurbitacin I, a naturally occurring triterpene analog, is a novel, potent and selective inhibitor of JAK2/STAT3 with potent anti-cancer activity on a variety of cancer cell types. |
|
V2003 | Artesunate | 88495-63-0 | Artesunate (Amivas; SM-804; WR-256283; HSDB-7458;Armax 200), an approved antimalaria agent, is a semisynthetic derivative of artemisinin with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. |
|
V9650 | Homoharringtonine (HHT) | 26833-87-4 | Homoharringtonine (Omacetaxine mepesuccinate and HHT; trade name Synribo) is a naturally occurring and cytotoxic pharmaceutical substance that is indicated for treatment of chronic myeloid leukemia (CML). |
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