EGFR

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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EGFR

The receptor tyrosine kinase family of the epidermal growth factor, which also includes HER2/neu (ErbB2), ErbB3 (HER3), and ErbB4 (HER4), includes the epidermal growth factor receptor (EGFR; ErbB1). The extracellular ligand-binding ectodomain, the single chain transmembrane domain, and the intracellular tyrosine kinase domain make up the EGFR, which is located at the cell surface. Epidermal growth factor (EGF), transforming growth factor (TGF-), amphiregulin, heparin-binding EGF, and betacellulin are just a few of the ligands that bind to and activate the EGFR.
The tyrosine kinase domain is activated by the receptors' formation of homo- or heterodimeric complexes after ligand binding. The Ras-Raf-MAP kinase, PI-3K/Akt, PKC, and Stat/Jak signaling pathways are all activated as a result of the dimerization and autophosphorylation of EGFR. The EGFR is activated to control cellular survival, differentiation, and proliferation. The EGFR has been derided as a proto-oncogene primarily because of its function in encouraging cell proliferation and preventing apoptosis.

EGFR related products

Cat No.	Product Name	CAS No.	Product Description
V69436	EGFR-IN-62	2890261-65-9	EGFR-IN-62 (compound 9h) is a potent EGFR kinase inhibitor (antagonist) with IC50s of 10 nM (L858R/T790 M), 29 nM (WT) and 242 nM (L858R/T790 M/C797S).
V69344	EGFR-IN-70	2926716-96-1	EGFR-IN-70 (compound 18j) is a potent EGFR inhibitor (antagonist) with IC50s of 23.6 and 307.5 nM for EGFRLR/TM/CS and EGFRWT, respectively.
V69421	EGFR-IN-73	2857033-34-0	EGFR-IN-73 (Compound 3f) is a potent inhibitor of EGFR Del19, the most common EGFR mutation, with IC50 of 119 nM.
V79266	EGFR-IN-74		EGFR-IN-74 (Compound 21) is a potent EGFR inhibitor (antagonist) with IC50 of 138 nM against EGFR L858R/T790M.
V80366	EGFR-IN-75		EGFR-IN-75 is an inhibitor (blocker/antagonist) of EGFRWT and EGFRT790M with IC50s of 0.28 μM and 5.02 μM, respectively.
V79152	EGFR-IN-78		EGFR-IN-78 (compound A5) is a 2-aminopyrimidine analogue, a reversible inhibitor of EGFRC797S-TK, and an inducer of apoptosis.
V79267	EGFR-IN-79		EGFR-IN-79 (compound 21) is an EGFR inhibitor (antagonist) with anti-tumor activity.
V69422	EGFR-IN-80	171745-13-4	EGFR-IN-80 (compound 30) is an EGFR inhibitor (antagonist) with pIC50 of 10.6.
V79268	EGFR-IN-81		EGFR-IN-81 (Compound 10i) is an EGFR inhibitor.
V69391	EGFR-IN-82	2568086-81-5	EGFR-IN-82 (Cmpound 8a) is an orally bioactive EGFR inhibitor (antagonist) with IC50s of 0.09 and 0.06 nM for EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S, respectively, but has no obvious effect on EGFRWT.
V79490	EGFR-IN-83		EGFR-IN-83 (Compound 9) is an EGFR inhibitor (IC50= 2.53 nM).
V79269	EGFR-IN-84		EGFR-IN-84 (Compound 6g) is an EGFR inhibitor (IC50= 24 nM).
V69353	EGFR-IN-85	1956378-29-2	EGFR-IN-85 (Compound 1) is an EGFR inhibitor.
V79925	EGFR-IN-86		EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC50= 1.5 nM) with high activity against glioblastoma.
V69377	EGFR-IN-87	1835666-87-9	EGFR-IN-87 is an EGFR tyrosine kinase inhibitor.
V69418	EGFR-IN-89	2413029-40-8	EGFR-IN-89 (compound 13k) is a potent fourth-generation EGFR mutation inhibitor (antagonist) with IC50 of 10.1 nM against Del19/T790M/C797S mutation.
V69431	EGFR-IN-9	1226549-39-8	EGFR-IN-9 (Compound 8) is a potent EGFR kinase inhibitor (antagonist) with IC50s of 7 nM and 28 nM for wild-type EGFR kinase and double mutant EGFR kinase (L858R/T790M), respectively.
V79270	EGFR-IN-90		EGFR-IN-90 (compound 34) is an orally bioactive EGFR inhibitor.
V79399	EGFR-IN-91		EGFR-IN-91 (compound 9) is an orally bioavailable EGFR inhibitor that can penetrate the BBB (blood-brain barrier).
V69432	EGFR/BRAF-IN-1	2906174-89-6	EGFR/BRAF-IN-1 (compound 21) is a 2,3-dihydropyrazino[1,2-a]indole-1,4-dione analogue, a potent EGFR/BRAF inhibitor, with IC50 of BRAFV600E is 45 nM.