EGFR

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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EGFR

The receptor tyrosine kinase family of the epidermal growth factor, which also includes HER2/neu (ErbB2), ErbB3 (HER3), and ErbB4 (HER4), includes the epidermal growth factor receptor (EGFR; ErbB1). The extracellular ligand-binding ectodomain, the single chain transmembrane domain, and the intracellular tyrosine kinase domain make up the EGFR, which is located at the cell surface. Epidermal growth factor (EGF), transforming growth factor (TGF-), amphiregulin, heparin-binding EGF, and betacellulin are just a few of the ligands that bind to and activate the EGFR.
The tyrosine kinase domain is activated by the receptors' formation of homo- or heterodimeric complexes after ligand binding. The Ras-Raf-MAP kinase, PI-3K/Akt, PKC, and Stat/Jak signaling pathways are all activated as a result of the dimerization and autophosphorylation of EGFR. The EGFR is activated to control cellular survival, differentiation, and proliferation. The EGFR has been derided as a proto-oncogene primarily because of its function in encouraging cell proliferation and preventing apoptosis.

EGFR related products

Cat No.	Product Name	CAS No.	Product Description
V69395	Duligotuzumab (MEHD-7945A; RG 7597)	1314238-96-4	Duligotuzumab (MEHD-7945A; RG 7597) is a humanized IgG-κ monoclonal antibody (mAb) that specifically targets Her3 (ErbB3).
V69348	DZD1516	2387570-00-3	DZD1516 is a potent and specific HER2 inhibitor (IC50=0.56 nM) with good blood-brain permeability.
V2600	EAI045	1942114-09-1	EAI045 (EAI-045) is a 4th generation selective & allosteric EGFR inhibitor overcoming T790M and C797S resistance.
V20419	EGFR inhibitor	879127-07-8	EGFR inhibitor is a novel and potent EGFR inhibitor which directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics.
V79256	EGFR kinase inhibitor 2		EGFR kinase inhibitor 2 (compound A-7) is a potent EGFR inhibitor targeting EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S mutants.
V79257	EGFR mutant-IN-1		EGFR mutant-IN-1 is a 5-methylpyrimidinone analogue that is a potent and specific inhibitor of EGFRL858R/T790M/C797S mutations with IC50 of 27.5 nM and a significantly lower inhibitory effect on EGFRWT (IC50 > 1.0 μM).
V69386	EGFR mutant-IN-2	2770009-06-6	EGFR mutant-IN-2 (Compound D51) is an EGFR mutation inhibitor.
V69349	EGFR Protein Tyrosine Kinase Substrate	945830-38-6	EGFR PTK (protein tyrosine kinase) Substrate is a substrate of EGFR tyrosine kinase.
V77049	EGFR T790M/L858R-IN-2		EGFRT790M/L858R-IN-2 is a potent and specific EGFRT790M/L858R inhibitor (antagonist) with IC50s of 3.5 and 1290 nM for EGFRT790M/L858R and EGFR WT respectively.
V69404	EGFR-IN-1 TFA	2753348-63-7	EGFR-IN-1 TFA is an orally bioactive, irreversible, mutant-selective L858R/T790M EGFR inhibitor.
V69414	EGFR-IN-15	2573869-16-4	EGFR-IN-15 (compound I-005) is an EGFR inhibitor (antagonist) with IC50 of 4 nM.
V69427	EGFR-IN-16	133550-22-8	EGFR-IN-16 (compound 3) is a potent EGFR inhibitor (antagonist) with pIC50s of 4.85 and 4.74 for EGFR and HER-2, respectively.
V69417	EGFR-IN-17	2817679-31-3	EGFR-IN-17 is a potent and specific epidermal growth factor receptor (EGFR) inhibitor (IC50 0.0002 μM) designed to overcome C797S-mediated drug resistance.
V69367	EGFR-IN-18	2765573-34-8	EGFR-IN-18 can effectively inhibit the enzymatic activity of L858R/T790M/C797S mutant EGFR (4.9 nM), and the enzymatic activity of wild-type EGFR (47 nM) is also reduced.
V69437	EGFR-IN-22	2634646-14-1	EGFR-IN-22 is a potent EGFR inhibitor (antagonist) with IC50 of 4.91 nM and 0.54 nM against wild-type EGFR and EGFRL858R/T790M/C797S, respectively (CN112538072A, compound 243).
V69371	EGFR-IN-24	2757548-54-0	EGFR-IN-24 is a potent EGFR inhibitor that can suppress EGFR (del19/T790M/C797S) and EGFR (L858R/T790M/C797S) respectively.
V69428	EGFR-IN-45	2765560-03-8	EGFR-IN-45 is a potent pan-inhibitor of epidermal growth factor receptor (EGFR) with IC50s of 0.4 µM and 1.6 µM for EGFR and CDK2, respectively.
V69389	EGFR-IN-48	2882851-77-4	EGFR-IN-48 is a potent and orally bioactive EGFR inhibitor (antagonist) with IC50s of 0.193 nM, 0.251 nM, and 10.4 nM for EGFRd19/TM/CS, EGFRLR/TM/CS, and EGFRWT respectively.
V31523	EGFR-IN-5	2225887-26-1	EGFR-IN-5 is a novel and potent EGFR-TKI with potential anticancer effects.
V69430	EGFR-IN-61	2890261-81-9	EGFR-IN-61 (compound 22a) is a potent EGFR kinase inhibitor (antagonist) with IC50s of 42 nM (L858R/T790 M), 137 nM (L858R/T790 M/C797S) and 743 nM (WT).