Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight.By directly controlling target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and member of the nuclear receptor superfamily, vitamin D modifies its biological effects. Vitamin D must undergo two hydroxylation steps in order to become the biologically active hormone 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], which communicates through the VDR, whether it is produced in the skin or consumed. In reaction to vitamin D, the hormone-bound VDR modifies target gene transcription. VDR controls autophagy's transcription at the master level. In breast cancer (BC) cells, vitamin D-activated VDR causes autophagy and an autophagic transcriptional signature.
Vitamin D comes in two different forms. Vitamin D3 (cholecalciferol) is produced in the skin and is found in oily fish and cod liver oil. Vitamin D2 (ergocalciferol) is produced by irradiating yeast and the plant sterol ergosterol. Vitamin D stands for vitamins D2 and D3.
For the treatment of psoriasis, topical medications containing active vitamin D3 (calcitriol, 1,25-dihydroxyvitaminD3, VD3) analogues, such as Tacalcitol, Calcipotriol, and Maxacalcitol, are frequently utilized.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V102440 | (1R,5Z)-Calcitriol | 32511-63-0 | (1R,5Z)-Calcitriol ((1R,5Z)-1,25-dihydroxyvitamin D3) is an isomer of calcitriol. |
|
V67836 | (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) | 61476-45-7 | (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). |
|
V109763 | (1S)-Calcitriol-d3 | 1539301-06-8 | (1S)-calcitriol-d3 (1α,25-dihydroxy-3-epio-vitamin D3-d3) is a deuterated (1S)-calcitriol. |
|
V109779 | (1S)-Calcitriol-d6 | 1202355-83-6 | (1S)-calcitriol-d6 (1α,25-dihydroxy-3-epio-vitamin D3-d6) is a deuterated (1S)-calcitriol. |
|
V111912 | 19-Nor-22-oxa-1a,25(OH)2-VD3 | 284041-36-7 | 19-nor-22-oxa-1a,25(OH)₂-VD₃ is a vitamin D₃ analogue. |
|
V20676 | Ercalcitriol (RO-17-6218) | 60133-18-8 | Ercalcitriol (RO-17-6218 or 1,25-dihydroxyvitamin D2, 1α,25-Dihydroxy Vitamin D2) is the active metabolite and circulating form of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney. |
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V67832 | 22-Hydroxyvitamin D3 | 110927-46-3 | 22-Hydroxyvitamin D3 is a novel vitamin D analogue that does not display vitamin D agonist activity in the intestine or bone. |
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V110699 | 24R-Calcipotriol-d4 | 24R-calcipotriol-d4 (PRI 2202-d4; impurity D of calcipotriol-d4) is deuterated 24R-calcipotriol. | |
|
V67843 | 2MD | 213250-70-5 | 2MD is an orally bioactive vitamin D analogue. |
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V5281 | 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 | 163018-26-6 | 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 analogue. |
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V116595 | AC-340 | AC-340 is a potent VDR agonist/HDAC inhibitor hybrid molecule. | |
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V78546 | Alfacalcidol-d7 (1-hydroxycholecalciferol-d7; 1.alpha.-Hydroxyvitamin D3-d7) | Alfacalcidol-d7 is the deuterated form of Alfacalcidol. | |
|
V89109 | Butyrate-Vitamin D3 | 31316-20-8 | Butyrate-Vitamin D3 (Butyrate-Cholecalciferol) is a derivative of vitamin D3 in which one of the hydroxyl groups in the vitamin D3 molecule is replaced by a butyrate group. |
|
V67835 | Calcifediol-d3 (25-hydroxy Vitamin D3-d3) | 140710-94-7 | Calcifediol-d3 is the deuterated form of Calcifediol. |
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V67842 | Calcifediol-d6 monohydrate (25-hydroxy Vitamin D3-d6 (monohydrate)) | 2483831-70-3 | Calcifediol-d6 (monohydrate) is the deuterated form of Calcifediol monohydrate. |
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V67840 | Calcitriol-d3 (1,25-Dihydroxyvitamin D3-d3) | 128723-16-0 | Calcitriol-d3 is the deuterated form of Calcitriol. |
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V109657 | Calcitriol-d9 | 1539301-39-7 | Calcitriol-d9 (1,25-dihydroxyvitamin D3-d9) is deuterated calcitriol. |
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V109517 | Calcitroic acid-13C | 1637678-42-2 | Calcitriol-13C is a 13C-labeled calcitriol. |
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V77044 | Eldecalcitol-d6 (Eldecalcitol d6) | Eldecalcitol-d6 is a deuterated form of Eldecalcitol. | |
|
V109687 | Ercalcidiol-13C3 | 1325307-59-2 | Icariol-13C3 (25-hydroxyvitamin D2-13C3) is 13C-labeled ircalciol. |
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