Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus.Thyroid hormone (T3)-mediated biological activities are mediated by thyroid hormone receptors, ligand-dependent transcription factors. Two genes, one for TR and the other for TR, encode the primary isoforms of thyroid hormone receptors, including TR1, TR2, TR1, and TR2. The pleiotropic effects of the thyroid hormone (T3) on growth, development, and differentiation as well as the preservation of metabolic equilibrium are mediated by the thyroid hormone receptors.
Thyroid hormone receptors are zinc finger transcription factors belonging to the erbA superfamily that bind to DNA at particular response element sequences called TREs and trigger gene expression in response to thyroid hormone (T3). It has been demonstrated that thyroid hormone receptors can form monomers, homodimers, or heterodimers with the retinoid X receptor (RXR), another member of the erbA superfamily, to bind DNA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76658 | Parathyroid Hormone (1-34), human, biotinylated | Parathyroid Hormone (1-34), human, biotinylated is a probe for parathyroid hormone receptors that may be utilized to analyze the interaction between parathyroid hormone and parathyroid hormone receptors in living cells and through affinity columns Purified hormone-receptor complexes. | |
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V67825 | pTH (39-84) (human) | 90880-43-6 | pTH (39-84) (human) is the C-terminal fragment of parathyroid hormone (PTH). |
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V67820 | pTH (53-84) (human) | 89439-30-5 | pTH (53-84) (human) is a fragment of human parathyroid hormone (pTH). |
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V62831 | Reverse T3-13C6 hydrochloride (3′,5′,3-Triiodothyronine-13C6 (hydrochloride)) | 1217676-14-6 | Reverse T3-13C6 (HCl) is 13C (carbon 13) labeled Reverse T3. |
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V7512 | Sobetirome (GC1; QRX431) | 211110-63-3 | Sobetirome (GC-1; QRX-431) is a novel, potent and selective thyroid hormone receptor-beta (TRβ) agonist with cholesterol-lowering effects. |
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V67816 | T3-ATA (S-isomer) | 2438721-48-1 | T3-ATA S-isomer is the S-isomer of T3-ATA, the active form of thyroid hormone. |
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V67831 | T4-ATA (S-isomer) | 2448470-97-9 | T4-ATA S-isomer is the S-isomer of T4-ATA, the active form of thyroid hormone. |
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V15711 | Taltirelin (TA0910) | 103300-74-9 | Taltirelin(TA-0910; tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog and a TRH mimic that acts as a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release). |
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V32625 | Taltirelin acetate (TA0910; Ceredist) | 1549593-23-8 | Taltirelin acetate (TA-0910; tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog and a TRH mimic that acts as a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release). |
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V67822 | THR-β modulator-1 | 2770373-00-5 | THR-β modulator-1 (compound 1a) is a potent thyroid hormone receptor beta modulator. |
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V67827 | THR-βagonist 6 | 2791290-58-7 | THR-β agonist 6 is an orally bioactive, selective thyroid hormone receptor β (THR-β) agonist/activator with EC50s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. |
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V67821 | THRβ receptor agonist-1 | 2403721-00-4 | THRβ receptor agonist (activator)-1 is an agonist of THRβ receptor. |
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V67813 | Thyroid hormone receptor beta agonist-1 | 2140902-80-1 | Thyroid hormone receptor beta agonist-1 (compound 3) is a thyroid beta agonist. |
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V63577 | Thyroxine hydrochloride-13C6 (L-Thyroxine-13C6; Levothyroxine-13C6; T4-13C6) | 1421769-38-1 | Thyroxine HCl-13C6 is a 13C (carbon 13)-labeled L-Thyroxine. |
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V67823 | TI17 | 1005178-02-8 | TI17 is an inhibitor (blocker/antagonist) of the thyroid hormone receptor-interacting protein Trip13 and has anti-neoplastic activity. |
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V67830 | TRβagonist 1 | 2770681-85-9 | TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor beta (TRβ) agonist/activator with EC50 of 21 nM. |
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