Estrogen receptors are a group of proteins found inside cells.They are receptors that the estrogen (17-estradiol) hormone activates. There are two classes of estrogen receptors: GPER (GPR30), a member of the rhodopsin-like family of G protein-coupled receptors, and ER, a member of the nuclear hormone family of intracellular receptors. The interactions between coactivators and corepressors, and consequently, the agonist or antagonist effect of the ligand, are heavily influenced by the ER's helix 12 domain.Different ligands may have different affinities for the estrogen receptor's alpha and beta isoforms. Estradiol binds to both receptors equally well, however raloxifene, estrone, and genistein bind preferentially to the alpha receptor. In addition to being necessary for sexual maturation and reproductive function, estrogen and its receptors also affect other tissues, like bone. In pathological conditions like osteoporosis, endometrial cancer, and breast cancer, estrogen receptors play a role. Numerous transcript variations are produced by alternative promoter use and alternative splicing, however it is unknown how many of these variants are full-length.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V51575 | SNIPER(ER)-87 | 2222354-91-6 | ERα degrader |
|
V67669 | Taragarestrant meglumine (D-0502 meglumine) | 2446618-18-2 | Taragarestrant (D-0502) meglumine is a potent, orally bioactive, selective estrogen receptor degrader. |
|
V3240 | WAY 200070 | 440122-66-7 | WAY-200070 (WAY200070) is a novel and selective agonist of the estrogen receptor β (ERRβ) with antidepressant effects. |
|
V28256 | XCT790 | 725247-18-7 | XCT790 is a selective ERRα antagonist/inverse agonist (IC50 = ~400 nM). |
|
V67701 | Yp537 (Anti-estrogen) | 166664-90-0 | Yp537 is an estrogen receptor (ER) inhibitor that prevents dimerization of the human estrogen receptor. |
|
V67683 | Zuclomiphene-d4 citrate | 2714316-71-7 | Zuclomiphene-d4 (citrate) is the deuterated form of Zuclomiphene citrate. |
|
V67681 | Zuclomiphene-d5 citrate | 1795132-80-7 | Zuclomiphene-d5 (citrate) is the deuterated form of Zuclomiphene citrate. |
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