| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
|
||
| 10mg |
|
||
| 25mg |
|
||
| 50mg |
|
||
| 100mg |
|
||
| 250mg |
|
||
| Other Sizes |
|
XCT790 is a selective ERRα antagonist/inverse agonist (IC50 = ~400 nM). At concentrations below 10 μM, XCT790 does not demonstrate any antagonist activity at ERRγ or ERα. It disrupts the signaling that is dependent on the PPARγ coactivator-1α (PGC-1α) and Errα.
| Targets |
ERα (IC50 = 0.37 μM)
|
|---|---|
| ln Vitro |
XCT-790 (0-40 μM; 48 hours and 72 hours) has a dose-dependent effect on MES-SA, MES-SA/DX5, and HepG2 cell viability[1].
XCT-790 (10 μM; 24 hours and 48 hours) reduces the the ERRα protein levels in HepG2 and R-HepG2 cell lines within 24 hours and keeps them there for 48 hours[1]. XCT-790 (10 μM; 48 hours) provokes apoptosis in both cell lines, HepG2 being more sensitive than R-HepG2[1]. |
| ln Vivo |
XCT-790 (XCT790; 4 mg/kg; intravenous injection; every three days; for 3 weeks; BALB/c mice) induces apoptosis in xenograft models without causing a decrease in body weight and significantly inhibits tumor growth and angiogenesis[3].
|
| Animal Protocol |
Female BALB/c mice (4 weeks of age) with HEC-1A xenograft[3]
4 mg/kg Intravenous injection; every three days; for 3 weeks |
| References |
|
| Molecular Formula |
C23H13F9N4O3S
|
|---|---|
| Molecular Weight |
596.43
|
| Exact Mass |
596.0565
|
| Elemental Analysis |
C, 46.32; H, 2.20; F, 28.67; N, 9.39; O, 8.05; S, 5.38
|
| CAS # |
725247-18-7
|
| Related CAS # |
725247-18-7
|
| Appearance |
Solid powder
|
| SMILES |
COC1=C(C=CC(=C1)/C=C(\C#N)/C(=O)NC2=NN=C(S2)C(F)(F)F)OCC3=C(C=C(C=C3)C(F)(F)F)C(F)(F)F
|
| InChi Key |
HQFNFOOGGLSBBT-AWNIVKPZSA-N
|
| InChi Code |
InChI=1S/C23H13F9N4O3S/c1-38-17-7-11(6-13(9-33)18(37)34-20-36-35-19(40-20)23(30,31)32)2-5-16(17)39-10-12-3-4-14(21(24,25)26)8-15(12)22(27,28)29/h2-8H,10H2,1H3,(H,34,36,37)/b13-6+
|
| Chemical Name |
(E)-3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide
|
| Synonyms |
XCT790; XCT-790; XCT 790
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 8~16.7 mg/mL (13.4~28 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 1.67 mg/mL (2.80 mM) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6766 mL | 8.3832 mL | 16.7664 mL | |
| 5 mM | 0.3353 mL | 1.6766 mL | 3.3533 mL | |
| 10 mM | 0.1677 mL | 0.8383 mL | 1.6766 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
